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Deleting titin’s I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function
Titin, the largest protein known, forms a giant filament in muscle where it spans the half sarcomere from Z disk to M band. Here we genetically targeted a stretch of 14 immunoglobulin-like and fibronectin type 3 domains that comprises the I-band/A-band (IA) junction and obtained a viable mouse model...
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| Hlavní autoři: | , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4210014/ https://ncbi.nlm.nih.gov/pubmed/25246556 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1411493111 |
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