Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model

by Alzubi, Jamal, Pallant, Celeste, Mussolino, Claudio, Howe, Steven J., Thrasher, Adrian J., Cathomen, Toni
Published in Sci Rep (2017)

Tolerance Induction Using Lentiviral Gene Delivery Delays Onset and Severity of Collagen II Arthritis

by Gjertsson, Inger, Laurie, Karen L, Devitt, James, Howe, Steven J, Thrasher, Adrian J, Holmdahl, Rikard, Gustafsson, Kenth
Published 2009

Inhibition of Mitochondrial Complex I Impairs Release of α-Galactosidase by Jurkat Cells

by Lambert, Jonathan R. A., Howe, Steven J., Rahim, Ahad A., Burke, Derek G., Heales, Simon J. R.
Published in Int J Mol Sci (2019)

Minicircle DNA Provides Enhanced and Prolonged Transgene Expression Following Airway Gene Transfer

by Munye, Mustafa M., Tagalakis, Aristides D., Barnes, Josephine L., Brown, Rachel E., McAnulty, Robin J., Howe, Steven J., Hart, Stephen L.
Published in Sci Rep (2016)

Lentiviral vectors containing an enhancer-less ubiquitously acting chromatin opening element (UCOE) provide highly reproducible and stable transgene expression in hematopoietic cel...

by Zhang, Fang, Thornhill, Susannah I., Howe, Steven J., Ulaganathan, Meera, Schambach, Axel, Sinclair, Joanna, Kinnon, Christine, Gaspar, H. Bobby, Antoniou, Michael, Thrasher, Adrian J.
Published 2007

Perinatal Gene Transfer to the Liver

by McKay, Tristan R, Rahim, Ahad A, Buckley, Suzanne M.K, Ward, Natalie J, Chan, Jerry K.Y, Howe, Steven J, Waddington, Simon N
Published 2011

Evidence for Contribution of CD4+CD25+ Regulatory T Cells in Maintaining Immune Tolerance to Human Factor IX following Perinatal Adenovirus Vector Delivery

by Nivsarkar, Megha S., Buckley, Suzanne M. K., Parker, Alan L., Perocheau, Dany, McKay, Tristan R., Rahim, Ahad A., Howe, Steven J., Waddington, Simon N.
Published in J Immunol Res (2015)

Gene Delivery of a Mutant TGFβ3 Reduces Markers of Scar Tissue Formation After Cutaneous Wounding

by Waddington, Simon N, Crossley, Rachel, Sheard, Vicky, Howe, Steven J, Buckley, Suzanne MK, Coughlan, Lynda, Gilham, David E, Hawkins, Robert E, McKay, Tristan R
Published 2010

The Landscape of Early Clinical Gene Therapies outside of Oncology

by Rittié, Laure, Athanasopoulos, Takis, Calero-Garcia, Miguel, Davies, Marie L., Dow, David J., Howe, Steven J., Morrison, Alastair, Ricciardelli, Ida, Saudemont, Aurore, Jespers, Laurent, Clay, Timothy M.
Published in Mol Ther (2019)

Lentiviral vectors can be used for full-length dystrophin gene therapy

by Counsell, John R., Asgarian, Zeinab, Meng, Jinhong, Ferrer, Veronica, Vink, Conrad A., Howe, Steven J., Waddington, Simon N., Thrasher, Adrian J., Muntoni, Francesco, Morgan, Jennifer E., Danos, Olivier
Published in Sci Rep (2017)

Lentiviral vectors can be used for full-length dystrophin gene therapy

by Counsell, John R., Asgarian, Zeinab, Meng, Jinhong, Ferrer, Veronica, Vink, Conrad A., Howe, Steven J., Waddington, Simon N., Thrasher, Adrian J., Muntoni, Francesco, Morgan, Jennifer E., Danos, Olivier
Published in Sci Rep (2017)

Erratum: Lentiviral vectors can be used for full-length dystrophin gene therapy

by Counsell, John R., Asgarian, Zeinab, Meng, Jinhong, Ferrer, Veronica, Vink, Conrad A., Howe, Steven J., Waddington, Simon N., Thrasher, Adrian J., Muntoni, Francesco, Morgan, Jennifer E., Danos, Olivier
Published in Sci Rep (2017)

Self-inactivating Gammaretroviral Vectors for Gene Therapy of X-linked Severe Combined Immunodeficiency

by Thornhill, Susannah I, Schambach, Axel, Howe, Steven J, Ulaganathan, Meera, Grassman, Elke, Williams, David, Schiedlmeier, Bernhard, Sebire, Neil J, Gaspar, H Bobby, Kinnon, Christine, Baum, Christopher, Thrasher, Adrian J
Published in Mol Ther (2008)

BMI-1 extends proliferative potential of human bronchial epithelial cells while retaining their mucociliary differentiation capacity

by Munye, Mustafa M., Shoemark, Amelia, Hirst, Robert A., Delhove, Juliette M., Sharp, Tyson V., McKay, Tristan R., O’Callaghan, Christopher, Baines, Deborah L., Howe, Steven J., Hart, Stephen L.
Published in Am J Physiol Lung Cell Mol Physiol (2017)

Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors

by Alonso-Ferrero, Maria E., van Til, Niek P., Bartolovic, Kerol, Mata, Márcia F., Wagemaker, Gerard, Moulding, Dale, Williams, David A., Kinnon, Christine, Waddington, Simon N., Milsom, Michael D., Howe, Steven J.
Published in Exp Hematol (2018)

Systemic gene delivery following intravenous administration of AAV9 to fetal and neonatal mice and late-gestation nonhuman primates

by Mattar, Citra N., Wong, Andrew M. S., Hoefer, Klemens, Alonso-Ferrero, Maria E., Buckley, Suzanne M. K., Howe, Steven J., Cooper, Jonathan D., Waddington, Simon N., Chan, Jerry K. Y., Rahim, Ahad A.
Published in FASEB J (2015)

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

by Vink, Conrad A., Counsell, John R., Perocheau, Dany P., Karda, Rajvinder, Buckley, Suzanne M.K., Brugman, Martijn H., Galla, Melanie, Schambach, Axel, McKay, Tristan R., Waddington, Simon N., Howe, Steven J.
Published in Mol Ther (2017)

Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice

by Langford-Smith, Alexander, Wilkinson, Fiona L, Langford-Smith, Kia J, Holley, Rebecca J, Sergijenko, Ana, Howe, Steven J, Bennett, William R, Jones, Simon A, Wraith, JE, Merry, Catherine LR, Wynn, Robert F, Bigger, Brian W
Published 2012

In vivo bioimaging with tissue-specific transcription factor activated luciferase reporters

by Buckley, Suzanne M. K., Delhove, Juliette M. K. M., Perocheau, Dany P., Karda, Rajvinder, Rahim, Ahad A., Howe, Steven J., Ward, Natalie J., Birrell, Mark A., Belvisi, Maria G., Arbuthnot, Patrick, Johnson, Mark R., Waddington, Simon N., McKay, Tristan R.
Published in Sci Rep (2015)

Lentiviral Vector Integration Profiles Differ in Rodent Postmitotic Tissues

by Bartholomae, Cynthia C, Arens, Anne, Balaggan, Kamaljit S, Yáñez-Muñoz, Rafael J, Montini, Eugenio, Howe, Steven J, Paruzynski, Anna, Korn, Bernhard, Appelt, Jens Uwe, MacNeil, Angus, Cesana, Daniela, Abel, Ulrich, Glimm, Hanno, Naldini, Luigi, Ali, Robin R, Thrasher, Adrian J, von Kalle, Christof, Schmidt, Manfred
Published 2011