Lipid Nanoparticle Systems for Enabling Gene Therapies

Por Cullis, Pieter R., Hope, Michael J.
Publicado no Mol Ther (2017)

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

Por Thess, Andreas, Grund, Stefanie, Mui, Barbara L, Hope, Michael J, Baumhof, Patrick, Fotin-Mleczek, Mariola, Schlake, Thomas
Publicado no Mol Ther (2015)

Intracellular Delivery and Antibacterial Activity of Gentamicin Encapsulated in pH-Sensitive Liposomes

Por Lutwyche, Peter, Cordeiro, Carol, Wiseman, David J., St-Louis, Maryse, Uh, Mitchell, Hope, Michael J., Webb, Murray S., Finlay, B. Brett
Publicado em 1998

Antibacterial Efficacy against an In Vivo Salmonella typhimurium Infection Model and Pharmacokinetics of a Liposomal Ciprofloxacin Formulation

Por Webb, Murray S., Boman, Nancy L., Wiseman, David J., Saxon, Dawn, Sutton, Kym, Wong, Kim F., Logan, Patricia, Hope, Michael J.
Publicado em 1998

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Por Pardi, Norbert, Tuyishime, Steven, Muramatsu, Hiromi, Kariko, Katalin, Mui, Barbara L, Tam, Ying K, Madden, Thomas D, Hope, Michael J, Weissman, Drew
Publicado no J Control Release (2015)

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

Por Lutz, Johannes, Lazzaro, Sandra, Habbeddine, Mohamed, Schmidt, Kim Ellen, Baumhof, Patrick, Mui, Barbara L., Tam, Ying K., Madden, Thomas D., Hope, Michael J., Heidenreich, Regina, Fotin-Mleczek, Mariola
Publicado no NPJ Vaccines (2017)

Correction to “Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core”

Por Leung, Alex K. K., Hafez, Ismail M., Baoukina, Svetlana, Belliveau, Nathan M., Zhigaltsev, Igor V., Afshinmanesh, Elham, Tieleman, D. Peter, Hansen, Carl L., Hope, Michael J., Cullis, Pieter R.
Publicado em 2012

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

Por Leung, Alex K. K., Hafez, Ismail M., Baoukina, Svetlana, Belliveau, Nathan M., Zhigaltsev, Igor V., Afshinmanesh, Elham, Tieleman, D. Peter, Hansen, Carl L., Hope, Michael J., Cullis, Pieter R.
Publicado em 2012

mRNA mediates passive vaccination against infectious agents, toxins, and tumors

Por Thran, Moritz, Mukherjee, Jean, Pönisch, Marion, Fiedler, Katja, Thess, Andreas, Mui, Barbara L, Hope, Michael J, Tam, Ying K, Horscroft, Nigel, Heidenreich, Regina, Fotin‐Mleczek, Mariola, Shoemaker, Charles B, Schlake, Thomas
Publicado no EMBO Mol Med (2017)

Influence of Cationic Lipid Composition on Gene Silencing Properties of Lipid Nanoparticle Formulations of siRNA in Antigen-Presenting Cells

Por Basha, Genc, Novobrantseva, Tatiana I, Rosin, Nicole, Tam, Yuen Yi C, Hafez, Ismail M, Wong, Matthew K, Sugo, Tsukasa, Ruda, Vera M, Qin, June, Klebanov, Boris, Ciufolini, Marco, Akinc, Akin, Tam, Ying K, Hope, Michael J, Cullis, Pieter R
Publicado em 2011

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

Por Mui, Barbara L, Tam, Ying K, Jayaraman, Muthusamy, Ansell, Steven M, Du, Xinyao, Tam, Yuen Yi C, Lin, Paulo JC, Chen, Sam, Narayanannair, Jayaprakash K, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Akinc, Akin, Maier, Martin A, Cullis, Pieter, Madden, Thomas D, Hope, Michael J
Publicado em 2013

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

Por Pardi, Norbert, Secreto, Anthony J., Shan, Xiaochuan, Debonera, Fotini, Glover, Joshua, Yi, Yanjie, Muramatsu, Hiromi, Ni, Houping, Mui, Barbara L., Tam, Ying K., Shaheen, Farida, Collman, Ronald G., Karikó, Katalin, Danet-Desnoyers, Gwenn A., Madden, Thomas D., Hope, Michael J., Weissman, Drew
Publicado no Nat Commun (2017)

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

Por Jayaraman, Muthusamy, Ansell, Steven M, Mui, Barbara L, Tam, Ying K, Chen, Jianxin, Du, Xinyao, Butler, David, Eltepu, Laxman, Matsuda, Shigeo, Narayanannair, Jayaprakash K, Rajeev, Kallanthottathil G, Hafez, Ismail M, Akinc, Akin, Maier, Martin A, Tracy, Mark A, Cullis, Pieter R, Madden, Thomas D, Manoharan, Muthiah, Hope, Michael J
Publicado em 2012

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

Por Akinc, Akin, Querbes, William, De, Soma, Qin, June, Frank-Kamenetsky, Maria, Jayaprakash, K. Narayanannair, Jayaraman, Muthusamy, Rajeev, Kallanthottathil G, Cantley, William L, Dorkin, J Robert, Butler, James S, Qin, LiuLiang, Racie, Timothy, Sprague, Andrew, Fava, Eugenio, Zeigerer, Anja, Hope, Michael J, Zerial, Marino, Sah, Dinah WY, Fitzgerald, Kevin, Tracy, Mark A, Manoharan, Muthiah, Koteliansky, Victor, Fougerolles, Antonin de, Maier, Martin A
Publicado em 2010

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Por Maier, Martin A, Jayaraman, Muthusamy, Matsuda, Shigeo, Liu, Ju, Barros, Scott, Querbes, William, Tam, Ying K, Ansell, Steven M, Kumar, Varun, Qin, June, Zhang, Xuemei, Wang, Qianfan, Panesar, Sue, Hutabarat, Renta, Carioto, Mary, Hettinger, Julia, Kandasamy, Pachamuthu, Butler, David, Rajeev, Kallanthottathil G, Pang, Bo, Charisse, Klaus, Fitzgerald, Kevin, Mui, Barbara L, Du, Xinyao, Cullis, Pieter, Madden, Thomas D, Hope, Michael J, Manoharan, Muthiah, Akinc, Akin
Publicado em 2013

Zika virus protection by a single low dose nucleoside modified mRNA vaccination

Por Pardi, Norbert, Hogan, Michael J., Pelc, Rebecca S., Muramatsu, Hiromi, Andersen, Hanne, DeMaso, Christina R., Dowd, Kimberly A., Sutherland, Laura L., Scearce, Richard M., Parks, Robert, Wagner, Wendeline, Granados, Alex, Greenhouse, Jack, Walker, Michelle, Willis, Elinor, Yu, Jae-Sung, McGee, Charles E., Sempowski, Gregory D., Mui, Barbara L., Tam, Ying K., Huang, Yan-Jang, Vanlandingham, Dana, Holmes, Veronica M., Balachandran, Harikrishnan, Sahu, Sujata, Lifton, Michelle, Higgs, Stephen, Hensley, Scott E., Madden, Thomas D., Hope, Michael J., Karikó, Katalin, Santra, Sampa, Graham, Barney S., Lewis, Mark G., Pierson, Theodore C., Haynes, Barton F., Weissman, Drew
Publicado no Nature (2017)