Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

[Image: see text] Lipid nanoparticles (LNP) containing ionizable cationic lipids are the leading systems for enabling therapeutic applications of siRNA; however, the structure of these systems has not been defined. Here we examine the structure of LNP siRNA systems containing DLinKC2-DMA(an ionizabl...

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Detalhes bibliográficos
Main Authors: Leung, Alex K. K., Hafez, Ismail M., Baoukina, Svetlana, Belliveau, Nathan M., Zhigaltsev, Igor V., Afshinmanesh, Elham, Tieleman, D. Peter, Hansen, Carl L., Hope, Michael J., Cullis, Pieter R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434764/
https://ncbi.nlm.nih.gov/pubmed/22962627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp303267y
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