Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

Lipid nanoparticles (LNP) are the leading systems for in vivo delivery of small interfering RNA (siRNA) for therapeutic applications. Formulation of LNP siRNA systems requires rapid mixing of solutions containing cationic lipid with solutions containing siRNA. Current formulation procedures employ m...

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Autori principali: Belliveau, Nathan M, Huft, Jens, Lin, Paulo JC, Chen, Sam, Leung, Alex KK, Leaver, Timothy J, Wild, Andre W, Lee, Justin B, Taylor, Robert J, Tam, Ying K, Hansen, Carl L, Cullis, Pieter R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442367/
https://ncbi.nlm.nih.gov/pubmed/23344179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2012.28
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