Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetes

OBJECTIVE: Hyperglucagonemia is present in many forms of diabetes and contributes to hyperglycemia, and glucagon suppression can ameliorate diabetes in mice. Leptin, a glucagon suppressor, can also reverse diabetes in rodents. Lipid nanoparticle (LNP) delivery of small interfering RNA (siRNA) effect...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Neumann, Ursula H., Ho, Jessica S.S., Chen, Sam, Tam, Yuen Yi C., Cullis, Pieter R., Kieffer, Timothy J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641600/
https://ncbi.nlm.nih.gov/pubmed/29031717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.06.012
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