Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

Manipulation of gene expression in the brain is fundamental for understanding the function of proteins involved in neuronal processes. In this article, we show a method for using small interfering RNA (siRNA) in lipid nanoparticles (LNPs) to efficiently silence neuronal gene expression in cell cultu...

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Détails bibliographiques
Auteurs principaux: Rungta, Ravi L, Choi, Hyun B, Lin, Paulo JC, Ko, Rebecca WY, Ashby, Donovan, Nair, Jay, Manoharan, Muthiah, Cullis, Pieter R, MacVicar, Brian A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889191/
https://ncbi.nlm.nih.gov/pubmed/24301867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.65
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