Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain

Manipulation of gene expression in the brain is fundamental for understanding the function of proteins involved in neuronal processes. In this article, we show a method for using small interfering RNA (siRNA) in lipid nanoparticles (LNPs) to efficiently silence neuronal gene expression in cell cultu...

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Detalhes bibliográficos
Main Authors: Rungta, Ravi L, Choi, Hyun B, Lin, Paulo JC, Ko, Rebecca WY, Ashby, Donovan, Nair, Jay, Manoharan, Muthiah, Cullis, Pieter R, MacVicar, Brian A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3889191/
https://ncbi.nlm.nih.gov/pubmed/24301867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.65
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