Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

Sclerostin is a protein secreted by osteocytes that is encoded by the SOST gene; it decreases bone formation by reducing osteoblast differentiation through inhibition of the Wnt signaling pathway. Silencing the SOST gene using RNA interference (RNAi) could therefore be an effective way to treat oste...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Basha, Genc, Ordobadi, Mina, Scott, Wilder R, Cottle, Andrew, Liu, Yan, Wang, Haitang, Cullis, Pieter R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056992/
https://ncbi.nlm.nih.gov/pubmed/27623445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2016.68
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