Challenges of developing small-molecule kinase inhibitors for brain tumors and the need for emphasis on free drug levels

Autor Heffron, Timothy P
Vydáno v Neuro Oncol (2018)

Ladder Polyether Synthesis via Epoxide-Opening Cascades Directed by a Disappearing Trimethylsilyl Group

Autor Heffron, Timothy P., Simpson, Graham L., Merino, Estibaliz, Jamison, Timothy F.
Vydáno 2010

CNS Anticancer Drug Discovery and Development: 2016 conference insights

Autor Levin, Victor A, Abrey, Lauren E, Heffron, Timothy P, Tonge, Peter J, Dar, Arvin C, Weiss, William A, Gallo, James M
Vydáno v CNS Oncol (2017)

Non-Covalent Wild-Type-Sparing Inhibitors of EGFR T790M

Autor Lee, Ho-June, Schaefer, Gabriele, Heffron, Timothy P., Shao, Lily, Ye, Xiaofen, Sideris, Steve, Malek, Shiva, Chan, Emily, Merchant, Mark, La, Hank, Ubhayakar, Savita, Yauch, Robert L., Pirazzoli, Valentina, Politi, Katerina, Settleman, Jeff
Vydáno 2012

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR

Autor Heffron, Timothy P., Ndubaku, Chudi O., Salphati, Laurent, Alicke, Bruno, Cheong, Jonathan, Drobnick, Joy, Edgar, Kyle, Gould, Stephen E., Lee, Leslie B., Lesnick, John D., Lewis, Cristina, Nonomiya, Jim, Pang, Jodie, Plise, Emile G., Sideris, Steve, Wallin, Jeffrey, Wang, Lan, Zhang, Xiaolin, Olivero, Alan G.
Vydáno v ACS Med Chem Lett (2016)

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR

Autor Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Clausen, Saundra, Dotson, Jennafer, Eigenbrot, Charles, Elliott, Richard, Hanan, Emily J., Heald, Robert, Jackson, Philip, La, Hank, Lainchbury, Michael, Malek, Shiva, Mann, Sam E., Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen, Sideris, Steve, Wang, Shumei, Yen, Ivana, Yu, Christine, Heffron, Timothy P.
Vydáno v ACS Med Chem Lett (2015)

CNS Anticancer Drug Discovery and Development Conference White Paper

Autor Levin, Victor A., Tonge, Peter J., Gallo, James M., Birtwistle, Marc R., Dar, Arvin C., Iavarone, Antonio, Paddison, Patrick J., Heffron, Timothy P., Elmquist, William F., Lachowicz, Jean E., Johnson, Ted W., White, Forest M., Sul, Joohee, Smith, Quentin R., Shen, Wang, Sarkaria, Jann N., Samala, Ramakrishna, Wen, Patrick Y., Berry, Donald A., Petter, Russell C.
Vydáno v Neuro Oncol (2015)

Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation

Autor Hanan, Emily J., Eigenbrot, Charles, Bryan, Marian C., Burdick, Daniel J., Chan, Bryan K., Chen, Yuan, Dotson, Jennafer, Heald, Robert A., Jackson, Philip S., La, Hank, Lainchbury, Michael D., Malek, Shiva, Purkey, Hans E., Schaefer, Gabriele, Schmidt, Stephen, Seward, Eileen M., Sideris, Steve, Tam, Christine, Wang, Shumei, Yeap, Siew Kuen, Yen, Ivana, Yin, Jianping, Yu, Christine, Zilberleyb, Inna, Heffron, Timothy P.
Vydáno v J Med Chem (2014)