Positioning Metabolism as a Central Player in the Diabetic Heart

por Mereweather, Laura J., Montes Aparicio, Claudia N., Heather, Lisa C.
Publicado en J Lipid Atheroscler (2020)

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance

por Schroeder, Marie A., Cochlin, Lowri E., Heather, Lisa C., Clarke, Kieran, Radda, George K., Tyler, Damian J.
Publicado 2008

Changes in Cardiac Substrate Transporters and Metabolic Proteins Mirror the Metabolic Shift in Patients with Aortic Stenosis

por Heather, Lisa C., Howell, Neil J., Emmanuel, Yaso, Cole, Mark A., Frenneaux, Michael P., Pagano, Domenico, Clarke, Kieran
Publicado 2011

Determining In Vivo Regulation of Cardiac Pyruvate Dehydrogenase Based on Label Flux from Hyperpolarized [1-(13)C]Pyruvate

por Schroeder, Marie A., Atherton, Helen J., Heather, Lisa C., Griffin, Julian L., Clarke, Kieran, Radda, George K., Tyler, Damian J.
Publicado en NMR Biomed (2011)

Simultaneous in vivo assessment of cardiac and hepatic metabolism in the diabetic rat using hyperpolarized MRS

por Le Page, Lydia M., Ball, Daniel R., Ball, Vicky, Dodd, Michael S., Miller, Jack J., Heather, Lisa C., Tyler, Damian J.
Publicado en NMR Biomed (2016)

Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin

por Mansor, Latt S, Gonzalez, Eileen R, Cole, Mark A, Tyler, Damian J, Beeson, Jessica H, Clarke, Kieran, Carr, Carolyn A, Heather, Lisa C
Publicado 2013

The Role of PDH Inhibition in the Development of Hypertrophy in the Hyperthyroid Rat Heart: A Combined MRI and Hyperpolarized MRS Study

por Atherton, Helen J., Dodd, Michael S., Heather, Lisa C., Schroeder, Marie A., Griffin, Julian L., Radda, George K., Clarke, Kieran, Tyler, Damian J.
Publicado en Circulation (2011)

The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism

por Slingo, Mary, Cole, Mark, Carr, Carolyn, Curtis, Mary K., Dodd, Michael, Giles, Lucia, Heather, Lisa C., Tyler, Damian, Clarke, Kieran, Robbins, Peter A.
Publicado en Am J Physiol Heart Circ Physiol (2016)

Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol

por Kerr, Matthew, Miller, Jack J., Thapa, Dharendra, Stiewe, Sophie, Timm, Kerstin N., Aparicio, Claudia N. Montes, Scott, Iain, Tyler, Damian J., Heather, Lisa C.
Publicado en JCI Insight (2020)

Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined (13)C Hyperpolarized Magnetic Resonance and Echocardiography Study

por Le Page, Lydia M., Rider, Oliver J., Lewis, Andrew J., Ball, Vicky, Clarke, Kieran, Johansson, Edvin, Carr, Carolyn A., Heather, Lisa C., Tyler, Damian J.
Publicado en Diabetes (2015)

Real-time assessment of Krebs cycle metabolism using hyperpolarized (13)C magnetic resonance spectroscopy

por Schroeder, Marie A., Atherton, Helen J., Ball, Daniel R., Cole, Mark A., Heather, Lisa C., Griffin, Julian L., Clarke, Kieran, Radda, George K., Tyler, Damian J.
Publicado 2009

A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart

por Cole, Mark A., Murray, Andrew J., Cochlin, Lowri E., Heather, Lisa C., McAleese, Sara, Knight, Nicholas S., Sutton, Elizabeth, Jamil, Amira Abd, Parassol, Nadege, Clarke, Kieran
Publicado 2011

Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart

por Ashmore, Tom, Fernandez, Bernadette O, Branco-Price, Cristina, West, James A, Cowburn, Andrew S, Heather, Lisa C, Griffin, Julian L, Johnson, Randall S, Feelisch, Martin, Murray, Andrew J
Publicado en J Physiol (2014)

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus

por Faulkner, Ashton, Tamiato, Anita, Cathery, William, Rampin, Andrea, Caravaggi, Carlo Maria, Jover, Eva, Allen, Steve, Mellor, Harry, Hauton, David, Heather, Lisa C., Spinetti, Gaia, Madeddu, Paolo
Publicado en Diabetologia (2020)

L-Carnitine Stimulates In Vivo Carbohydrate Metabolism in the Type 1 Diabetic Heart as Demonstrated by Hyperpolarized MRI

por Savic, Dragana, Ball, Vicky, Curtis, M. Kate, Sousa Fialho, Maria da Luz, Timm, Kerstin N., Hauton, David, West, James, Griffin, Julian, Heather, Lisa C., Tyler, Damian J.
Publicado en Metabolites (2021)

Impaired In Vivo Mitochondrial Krebs Cycle Activity After Myocardial Infarction Assessed Using Hyperpolarized Magnetic Resonance Spectroscopy

por Dodd, Michael S., Atherton, Helen J., Carr, Carolyn A., Stuckey, Daniel J., West, James A., Griffin, Julian L., Radda, George K., Clarke, Kieran, Heather, Lisa C., Tyler, Damian J.
Publicado en Circ Cardiovasc Imaging (2014)

Validation of the In Vivo Assessment of Pyruvate Dehydrogenase Activity Using Hyperpolarized (13)C-Magnetic Resonance Spectroscopy

por Atherton, Helen J., Schroeder, Marie A., Dodd, Michael S., Heather, Lisa C., Carter, Emma E., Cochlin, Lowri E., Nagel, Simon, Sibson, Nicola R., Radda, George K., Clarke, Kieran, Tyler, Damian J.
Publicado en NMR Biomed (2010)

In Vivo Alterations in Cardiac Metabolism and Function in the Spontaneously Hypertensive Rat Heart

por Dodd, Michael S., Ball, Daniel R., Schroeder, Marie A., Le Page, Lydia M., Atherton, Helen J., Heather, Lisa C., Seymour, Anne-Marie, Ashrafian, Houman, Watkins, Hugh, Clarke, Kieran, Tyler, Damian J.
Publicado en Cardiovasc Res (2012)

Assessing the effect of hypoxia on cardiac metabolism using hyperpolarized (13)C magnetic resonance spectroscopy

por Le Page, Lydia M., Rider, Oliver J., Lewis, Andrew J., Noden, Victoria, Kerr, Matthew, Giles, Lucia, Ambrose, Lucy J.A., Ball, Vicky, Mansor, Latt, Heather, Lisa C., Tyler, Damian J.
Publicado en NMR Biomed (2019)

Rapid, [Formula: see text] ‐insensitive, dual‐band quasi‐adiabatic saturation transfer with optimal control for complete quantification of myocardial ATP flux

por Miller, Jack J., Valkovič, Ladislav, Kerr, Matthew, Timm, Kerstin N., Watson, William D., Lau, Justin Y. C., Tyler, Andrew, Rodgers, Christopher, Bottomley, Paul A., Heather, Lisa C., Tyler, Damian J.
Publicado en Magn Reson Med (2021)