Insights into the PI3-K-PKB-mTOR signalling pathway from small molecules

Por Gunn, Richard M., Hailes, Helen C.
Publicado em 2008

Identification and catalytic properties of new epoxide hydrolases from the genomic data of soil bacteria

Por Stojanovski, Gorjan, Dobrijevic, Dragana, Hailes, Helen C., Ward, John M.
Publicado no Enzyme Microb Technol (2020)

Enzyme catalysed Pictet-Spengler formation of chiral 1,1'-disubstituted- and spiro-tetrahydroisoquinolines

Por Lichman, Benjamin R., Zhao, Jianxiong, Hailes, Helen C., Ward, John M.
Publicado no Nat Commun (2017)

One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues

Por Zhao, Jianxiong, Lichman, Benjamin R., Ward, John M., Hailes, Helen C.
Publicado no Chem Commun (Camb) (2018)

Biomimetic Phosphate-Catalyzed Pictet–Spengler Reaction for the Synthesis of 1,1′-Disubstituted and Spiro-Tetrahydroisoquinoline Alkaloids

Por Zhao, Jianxiong, Méndez-Sánchez, Daniel, Ward, John M., Hailes, Helen C.
Publicado no J Org Chem (2019)

Highly Regioselective Synthesis of Substituted Isoindolinones via Ruthenium-Catalyzed Alkyne Cyclotrimerizations

Por Foster, Robert W, Tame, Christopher J, Hailes, Helen C, Sheppard, Tom D
Publicado em 2013

One–Pot Phosphate-Mediated Synthesis of Novel 1,3,5-Trisubstituted Pyridinium Salts: A New Family of S. aureus Inhibitors

Por Pesnot, Thomas, Gershater, Markus C., Edwards, Martin, Ward, John M., Hailes, Helen C.
Publicado no Molecules (2017)

Aminopolyols from Carbohydrates: Amination of Sugars and Sugar‐Derived Tetrahydrofurans with Transaminases

Por Subrizi, Fabiana, Benhamou, Laure, Ward, John M., Sheppard, Tom D., Hailes, Helen C.
Publicado no Angew Chem Int Ed Engl (2019)

Sustainable Synthesis of Chiral Tetrahydrofurans through the Selective Dehydration of Pentoses

Por Foster, Robert W, Tame, Christopher J, Bučar, Dejan-Krešimir, Hailes, Helen C, Sheppard, Tom D
Publicado no Chemistry (2015)

Effect of Liposomal Encapsulation on the Chemical Exchange Properties of Diamagnetic CEST Agents

Por Demetriou, Eleni, Story, Harriet E., Bofinger, Robin, Hailes, Helen C., Tabor, Alethea B., Golay, Xavier
Publicado no J Phys Chem B (2019)

Structural Analysis of an Evolved Transketolase Reveals Divergent Binding Modes

Por Affaticati, Pierre E., Dai, Shao-Bo, Payongsri, Panwajee, Hailes, Helen C., Tittmann, Kai, Dalby, Paul A.
Publicado no Sci Rep (2016)

Structural Evidence for the Dopamine-First Mechanism of Norcoclaurine Synthase

Por Lichman, Benjamin R., Sula, Altin, Pesnot, Thomas, Hailes, Helen C., Ward, John M., Keep, Nicholas H.
Publicado no Biochemistry (2017)

Data on a thermostable enzymatic one-pot reaction for the production of a high-value compound from l-arabinose

Por Bawn, Maria, Subrizi, Fabiana, Lye, Gary J., Sheppard, Tom D., Hailes, Helen C., Ward, John M.
Publicado no Data Brief (2018)

The identification and use of robust transaminases from a domestic drain metagenome

Por Leipold, Leona, Dobrijevic, Dragana, Jeffries, Jack W. E., Bawn, Maria, Moody, Thomas S., Ward, John M., Hailes, Helen C.
Publicado no Green Chem (2019)

Catalytic direct amidations in tert-butyl acetate using B(OCH(2)CF(3))(3)

Por Coomber, Charlotte E., Laserna, Victor, Martin, Liam T., Smith, Peter D., Hailes, Helen C., Porter, Michael J., Sheppard, Tom D.
Publicado no Org Biomol Chem (2019)

The substrate specificity, enantioselectivity and structure of the (R)-selective amine : pyruvate transaminase from Nectria haematococca

Por Sayer, Christopher, Martinez-Torres, Ruben J, Richter, Nina, Isupov, Michail N, Hailes, Helen C, Littlechild, Jennifer A, Ward, John M
Publicado no FEBS J (2014)

Irreversible endo-Selective Diels–Alder Reactions of Substituted Alkoxyfurans: A General Synthesis of endo-Cantharimides

Por Foster, Robert W, Benhamou, Laure, Porter, Michael J, Bučar, Dejan-Krešimir, Hailes, Helen C, Tame, Christopher J, Sheppard, Tom D
Publicado no Chemistry (2015)

Enzymatic and Chemoenzymatic Three‐Step Cascades for the Synthesis of Stereochemically Complementary Trisubstituted Tetrahydroisoquinolines

Por Erdmann, Vanessa, Lichman, Benjamin R., Zhao, Jianxiong, Simon, Robert C., Kroutil, Wolfgang, Ward, John M., Hailes, Helen C., Rother, Dörte
Publicado no Angew Chem Int Ed Engl (2017)

‘Dopamine-first’ mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile

Por Lichman, Benjamin R, Gershater, Markus C, Lamming, Eleanor D, Pesnot, Thomas, Sula, Altin, Keep, Nicholas H, Hailes, Helen C, Ward, John M
Publicado no FEBS J (2015)

ortho and para chromophores of green fluorescent protein: controlling electron emission and internal conversion

Por McLaughlin, Conor, Assmann, Mariana, Parkes, Michael A., Woodhouse, Joanne L., Lewin, Ross, Hailes, Helen C., Worth, Graham A., Fielding, Helen H.
Publicado no Chem Sci (2017)