‘Dopamine-first’ mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile

Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet–Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety. This unique activity has led to NCS being used for both in vitro biocatalysis and in vivo recombin...

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Bibliografiske detaljer
Udgivet i:FEBS J
Main Authors: Lichman, Benjamin R, Gershater, Markus C, Lamming, Eleanor D, Pesnot, Thomas, Sula, Altin, Keep, Nicholas H, Hailes, Helen C, Ward, John M
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2015
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4413047/
https://ncbi.nlm.nih.gov/pubmed/25620686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13208
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