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One-pot chemoenzymatic synthesis of trolline and tetrahydroisoquinoline analogues
Chemoenzymatic reaction cascades can provide access to chiral compounds from low-cost starting materials in one pot. Here we describe one-pot asymmetric routes to tetrahydroisoquinoline alkaloids (THIAs) using the Pictet–Spenglerase norcoclaurine synthase (NCS) followed by a cyclisation, to give alk...
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Publicado no: | Chem Commun (Camb) |
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Main Authors: | , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Royal Society of Chemistry
2018
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5804477/ https://ncbi.nlm.nih.gov/pubmed/29345260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7cc08024g |
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