Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvi...

Por Guo, Ailin, Lu, Pin, Coffey, Greg, Conley, Pamela, Pandey, Anjali, Wang, Y. Lynn
Publicado no Oncotarget (2017)

Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib

Por Guo, Ailin, Lu, Pin, Galanina, Natalie, Nabhan, Chadi, Smith, Sonali M., Coleman, Morton, Wang, Y. Lynn
Publicado no Oncotarget (2015)

Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma

Por Ma, Jiao, Xing, Wei, Coffey, Greg, Dresser, Karen, Lu, Kellie, Guo, Ailin, Raca, Gordana, Pandey, Anjali, Conley, Pamela, Yu, Hongbo, Wang, Y. Lynn
Publicado no Oncotarget (2015)

Ibrutinib Resistance in Chronic Lymphocytic Leukemia

Por Furman, Richard R., Cheng, Shuhua, Lu, Pin, Setty, Menu, Perez, Alexendar R., Guo, Ailin, Racchumi, Joelle, Xu, Guozhou, Wu, Hao, Ma, Jiao, Steggerda, Susanne M., Coleman, Morton, Leslie, Christina, Wang, Y. Lynn
Publicado no N Engl J Med (2014)

Activation of MYC, a bona fide client of HSP90, contributes to intrinsic ibrutinib resistance in mantle cell lymphoma

Por Lee, Jimmy, Zhang, Liang Leo, Wu, Wenjun, Guo, Hui, Li, Yan, Sukhanova, Madina, Venkataraman, Girish, Zhang, Hui, Alikhan, Mir, Lu, Pin, Guo, Ailin, Galanina, Natalie, Andrade, Jorge, Wang, Michael L., Wang, Y. Lynn
Publicado no Blood Adv (2018)

Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL

Por Sharma, Shruti, Galanina, Natalie, Guo, Ailin, Lee, Jimmy, Kadri, Sabah, Van Slambrouck, Charles, Long, Bradley, Wang, Weige, Ming, Mei, Furtado, Larissa V., Segal, Jeremy P., Stock, Wendy, Venkataraman, Girish, Tang, Wei-Jen, Lu, Pin, Wang, Yue Lynn
Publicado no Oncotarget (2016)

Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL

Por Kadri, Sabah, Lee, Jimmy, Fitzpatrick, Carrie, Galanina, Natalie, Sukhanova, Madina, Venkataraman, Girish, Sharma, Shruti, Long, Brad, Petras, Kristin, Theissen, Megan, Ming, Mei, Kobzev, Yuri, Kang, Wenjun, Guo, Ailin, Wang, Weige, Niu, Nifang, Weiner, Howard, Thirman, Michael, Stock, Wendy, Smith, Sonali M., Nabhan, Chadi, Segal, Jeremy P., Lu, Pin, Wang, Y. Lynn
Publicado no Blood Adv (2017)