Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL

Ibrutinib has generated remarkable responses in patients with chronic lymphocytic leukemia (CLL), including those with an unfavorable cytogenetic profile. However, patients develop resistance, with poor outcomes and no established treatment options. Mutations in BTK and PLCG2 have emerged as main me...

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Foilsithe in:Blood Adv
Main Authors: Kadri, Sabah, Lee, Jimmy, Fitzpatrick, Carrie, Galanina, Natalie, Sukhanova, Madina, Venkataraman, Girish, Sharma, Shruti, Long, Brad, Petras, Kristin, Theissen, Megan, Ming, Mei, Kobzev, Yuri, Kang, Wenjun, Guo, Ailin, Wang, Weige, Niu, Nifang, Weiner, Howard, Thirman, Michael, Stock, Wendy, Smith, Sonali M., Nabhan, Chadi, Segal, Jeremy P., Lu, Pin, Wang, Y. Lynn
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2017
Ábhair:
Lymphoid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728051/
https://ncbi.nlm.nih.gov/pubmed/29296715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016003632
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