Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL

Ibrutinib has generated remarkable responses in patients with chronic lymphocytic leukemia (CLL), including those with an unfavorable cytogenetic profile. However, patients develop resistance, with poor outcomes and no established treatment options. Mutations in BTK and PLCG2 have emerged as main me...

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Vydáno v:Blood Adv
Hlavní autoři: Kadri, Sabah, Lee, Jimmy, Fitzpatrick, Carrie, Galanina, Natalie, Sukhanova, Madina, Venkataraman, Girish, Sharma, Shruti, Long, Brad, Petras, Kristin, Theissen, Megan, Ming, Mei, Kobzev, Yuri, Kang, Wenjun, Guo, Ailin, Wang, Weige, Niu, Nifang, Weiner, Howard, Thirman, Michael, Stock, Wendy, Smith, Sonali M., Nabhan, Chadi, Segal, Jeremy P., Lu, Pin, Wang, Y. Lynn
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2017
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728051/
https://ncbi.nlm.nih.gov/pubmed/29296715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016003632
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