Identification of a structurally novel BTK mutation that drives ibrutinib resistance in CLL

Ibrutinib (ibr), a first-in-class Bruton tyrosine kinase (BTK) inhibitor, has demonstrated high response rates in both relapsed/refractory and treatment naïve chronic lymphocytic leukemia (CLL). However, about 25% of patients discontinue ibrutinib therapy at a median follow-up of 20 months and many...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Sharma, Shruti, Galanina, Natalie, Guo, Ailin, Lee, Jimmy, Kadri, Sabah, Van Slambrouck, Charles, Long, Bradley, Wang, Weige, Ming, Mei, Furtado, Larissa V., Segal, Jeremy P., Stock, Wendy, Venkataraman, Girish, Tang, Wei-Jen, Lu, Pin, Wang, Yue Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356593/
https://ncbi.nlm.nih.gov/pubmed/27626698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11932
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