Heightened BTK-dependent cell proliferation in unmutated chronic lymphocytic leukemia confers increased sensitivity to ibrutinib

In chronic lymphocytic leukemia (CLL), patients with unmutated immunoglobulin heavy chain variable region gene (UM-CLL) have worse outcomes than mutated CLL (M-CLL) following chemotherapy or chemoimmunotherapy. However, in the era of BCR-targeted therapies, the adverse prognostic impact of unmutated...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Guo, Ailin, Lu, Pin, Galanina, Natalie, Nabhan, Chadi, Smith, Sonali M., Coleman, Morton, Wang, Y. Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826229/
https://ncbi.nlm.nih.gov/pubmed/26717038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6727
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