Leukemia cell proliferation and death in chronic lymphocytic leukemia patients on therapy with the BTK inhibitor ibrutinib

BACKGROUND. Ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL) that inhibits Bruton’s tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. METHODS. We used stable isotopic labeling with deuterated water ((2)H(2)O) to measure directly the...

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Udgivet i:JCI Insight
Main Authors: Burger, Jan A., Li, Kelvin W., Keating, Michael J., Sivina, Mariela, Amer, Ahmed M., Garg, Naveen, Ferrajoli, Alessandra, Huang, Xuelin, Kantarjian, Hagop, Wierda, William G., O’Brien, Susan, Hellerstein, Marc K., Turner, Scott M., Emson, Claire L., Chen, Shih-Shih, Yan, Xiao-Jie, Wodarz, Dominik, Chiorazzi, Nicholas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Clinical Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256142/
https://ncbi.nlm.nih.gov/pubmed/28138560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89904
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