Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma

B-cell receptor (BCR) and JAK/STAT pathways play critical roles in diffuse large B-cell lymphoma (DLBCL). Herein, we investigated the anti-lymphoma activity of cerdulatinib, a novel compound that dually targets SYK and JAK/STAT pathways. On a tissue microarray of 62 primary DLBCL tumors, 58% express...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Ma, Jiao, Xing, Wei, Coffey, Greg, Dresser, Karen, Lu, Kellie, Guo, Ailin, Raca, Gordana, Pandey, Anjali, Conley, Pamela, Yu, Hongbo, Wang, Y. Lynn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791274/
https://ncbi.nlm.nih.gov/pubmed/26575169
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