Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment

Ibrutinib (BTK inhibitor) has generated remarkable responses in CLL. However, the drug, to a large extent, does not cause cell death directly and does not eradicate CLL malignant clones. Inability to eradicate CLL has fostered resistance generation. Once patients become resistant, they do poorly wit...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Guo, Ailin, Lu, Pin, Coffey, Greg, Conley, Pamela, Pandey, Anjali, Wang, Y. Lynn
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355069/
https://ncbi.nlm.nih.gov/pubmed/28088788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14588
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker