Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment

Ibrutinib (BTK inhibitor) has generated remarkable responses in CLL. However, the drug, to a large extent, does not cause cell death directly and does not eradicate CLL malignant clones. Inability to eradicate CLL has fostered resistance generation. Once patients become resistant, they do poorly wit...

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Bibliografische gegevens
Gepubliceerd in:Oncotarget
Hoofdauteurs: Guo, Ailin, Lu, Pin, Coffey, Greg, Conley, Pamela, Pandey, Anjali, Wang, Y. Lynn
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Impact Journals LLC 2017
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355069/
https://ncbi.nlm.nih.gov/pubmed/28088788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14588
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