Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs

von Gmeiner, William H.
Veröffentlicht in Cancer Drug Resist (2019)

Fluoropyrimidine Modulation of the Anti-Tumor Immune Response―Prospects for Improved Colorectal Cancer Treatment

von Gmeiner, William H.
Veröffentlicht in Cancers (Basel) (2020)

Chemistry of Fluorinated Pyrimidines in the Era of Personalized Medicine

von Gmeiner, William H.
Veröffentlicht in Molecules (2020)

Recent Advances in Our Knowledge of mCRC Tumor Biology and Genetics: A Focus on Targeted Therapy Development

von Gmeiner, William H
Veröffentlicht in Onco Targets Ther (2021)

Nanotechnology for cancer treatment

von Gmeiner, William H., Ghosh, Supratim
Veröffentlicht in Nanotechnol Rev (2013)

Improved potency of F10 relative to 5-fluorouracil in colorectal cancer cells with p53 mutations

von Dominijanni, Anthony, Gmeiner, William H.
Veröffentlicht in Cancer Drug Resist (2018)

Genome-Wide mRNA and microRNA Profiling of the NCI 60 Cell Line Screen and Comparison of FdUMP[10] with fluorouracil, floxuridine, and Top1 Poisons

von Gmeiner, William H., Reinhold, William C., Pommier, Yves
Veröffentlicht 2010

Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity

von Jennings-Gee, Jamie, Pardee, Timothy S., Gmeiner, William H.
Veröffentlicht 2012

All-atom MD indicates ion-dependent behavior of therapeutic DNA polymer

von Melvin, Ryan L., Gmeiner, William H., Salsbury, Freddie R.
Veröffentlicht in Phys Chem Chem Phys (2017)

All-Atom MD Predicts Magnesium-Induced Hairpin in Chemically Perturbed RNA Analog of F10 Therapeutic

von Melvin, Ryan L., Gmeiner, William H., Salsbury, Freddie R.
Veröffentlicht in J Phys Chem B (2017)

All-atom molecular dynamics comparison of disease-associated zinc fingers

von Godwin, Ryan C., Gmeiner, William H., Salsbury, Freddie R.
Veröffentlicht in J Biomol Struct Dyn (2017)

All-Atom Molecular Dynamics Reveals Mechanism of Zinc Complexation with Therapeutic F10

von Melvin, Ryan L., Gmeiner, William H., Salsbury, Freddie R.
Veröffentlicht in J Phys Chem B (2016)

Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages

von Boyacioglu, Olcay, Stuart, Christopher H, Kulik, George, Gmeiner, William H
Veröffentlicht 2013

F10 cytotoxicity via topoisomerase I cleavage complex repair consistent with a unique mechanism for thymineless death

von Gmeiner, William H, Gearhart, Patricia J, Pommier, Yves, Nakamura, Jun
Veröffentlicht in Future Oncol (2016)

Zn(2+) selectively stabilizes FdU-substituted DNA through a unique major groove binding motif

von Ghosh, Supratim, Salsbury, Freddie R., Horita, David A., Gmeiner, William H.
Veröffentlicht 2011

The Stability of a Model Substrate for Topoisomerase 1-Mediated DNA Religation Depends on the Presence of Mismatched Base Pairs

von Gmeiner, William H., Salsbury, Freddie, Olsen, Chris M., Marky, Luis A.
Veröffentlicht 2011

Cooperative Stabilization of Zn(2+):DNA Complexes Through Netropsin Binding in the Minor Groove of FdU-Substituted DNA

von Ghosh, Supratim, Salsbury, Freddie R., Horita, David A., Gmeiner, William H.
Veröffentlicht 2012

Thymineless Death in F10-Treated AML Cells Occurs via Lipid Raft Depletion and Fas/FasL co-Localization in the Plasma Membrane with Activation of the Extrinsic Apoptotic Pathway

von Gmeiner, William H., Jennings-Gee, Jamie, Stuart, Christopher H., Pardee, Timothy S.
Veröffentlicht in Leuk Res (2014)

The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence

von Gmeiner, William H, Debinski, Waldemar, Milligan, Carol, Caudell, David, Pardee, Timothy S
Veröffentlicht in Future Oncol (2016)

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

von Pardee, Timothy S., Gomes, Evan, Jennings-Gee, Jamie, Caudell, David, Gmeiner, William H.
Veröffentlicht 2012