Nanotechnology for cancer treatment

Por Gmeiner, William H., Ghosh, Supratim
Publicado no Nanotechnol Rev (2013)

Genome-Wide mRNA and microRNA Profiling of the NCI 60 Cell Line Screen and Comparison of FdUMP[10] with fluorouracil, floxuridine, and Top1 Poisons

Por Gmeiner, William H., Reinhold, William C., Pommier, Yves
Publicado em 2010

Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity

Por Jennings-Gee, Jamie, Pardee, Timothy S., Gmeiner, William H.
Publicado em 2012

Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages

Por Boyacioglu, Olcay, Stuart, Christopher H, Kulik, George, Gmeiner, William H
Publicado em 2013

Zn(2+) selectively stabilizes FdU-substituted DNA through a unique major groove binding motif

Por Ghosh, Supratim, Salsbury, Freddie R., Horita, David A., Gmeiner, William H.
Publicado em 2011

The Stability of a Model Substrate for Topoisomerase 1-Mediated DNA Religation Depends on the Presence of Mismatched Base Pairs

Por Gmeiner, William H., Salsbury, Freddie, Olsen, Chris M., Marky, Luis A.
Publicado em 2011

Cooperative Stabilization of Zn(2+):DNA Complexes Through Netropsin Binding in the Minor Groove of FdU-Substituted DNA

Por Ghosh, Supratim, Salsbury, Freddie R., Horita, David A., Gmeiner, William H.
Publicado em 2012

Thymineless Death in F10-Treated AML Cells Occurs via Lipid Raft Depletion and Fas/FasL co-Localization in the Plasma Membrane with Activation of the Extrinsic Apoptotic Pathway

Por Gmeiner, William H., Jennings-Gee, Jamie, Stuart, Christopher H., Pardee, Timothy S.
Publicado no Leuk Res (2014)

The applications of the novel polymeric fluoropyrimidine F10 in cancer treatment: current evidence

Por Gmeiner, William H, Debinski, Waldemar, Milligan, Carol, Caudell, David, Pardee, Timothy S
Publicado no Future Oncol (2016)

Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity

Por Pardee, Timothy S., Gomes, Evan, Jennings-Gee, Jamie, Caudell, David, Gmeiner, William H.
Publicado em 2012

The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells

Por Pardee, Timothy S., Stadelman, Kristin, Jennings-Gee, Jamie, Caudell, David L., Gmeiner, William H.
Publicado em 2014

Development of modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity

Por Wu, Shao-yu, Chen, Tian-min, Gmeiner, William H., Chu, Edward, Schmitz, John C.
Publicado em 2013

The Cytotoxic and Pro-Apoptotic Activities of the Novel Fluoropyrimidine F10 Towards Prostate Cancer Cells are Enhanced by Zn(2+)-Chelation and Inhibiting the Serine Protease Omi/H...

Por Gmeiner, William H., Boyacioglu, Olcay, Stuart, Christopher H., Jennings-Gee, Jamie, Balaji, K.C.
Publicado no Prostate (2014)

Selective anti-tumor activity of the novel fluoropyrimidine polymer F10 towards G48a orthotopic GBM tumors

Por Gmeiner, William H., Lema-Tome, Carla, Gibo, Denise, Jennings-Gee, Jamie, Milligan, Carol, Debinski, Waldemar
Publicado em 2013

NMR structure of the 3′ stem–loop from human U4 snRNA

Por Comolli, Luis R., Ulyanov, Nikolai B., Soto, Ana Maria, Marky, Luis A., James, Thomas L., Gmeiner, William H.
Publicado em 2002

Increased Heating Efficiency and Selective Thermal Ablation of Malignant Tissue with DNA-Encased Multiwalled Carbon Nanotubes

Por Ghosh, Supratim, Dutta, Samrat, Gomes, Evan, Carroll, David, D’Agostino, Ralph, Olson, John, Guthold, Martin, Gmeiner, William H.
Publicado em 2009

TDP1 repairs nuclear and mitochondrial DNA damage induced by chain-terminating anticancer and antiviral nucleoside analogs

Por Huang, Shar-yin N., Murai, Junko, Dalla Rosa, Ilaria, Dexheimer, Thomas S., Naumova, Alena, Gmeiner, William H., Pommier, Yves
Publicado em 2013

Site-Specific DNA–Doxorubicin Conjugates Display Enhanced Cytotoxicity to Breast Cancer Cells

Por Stuart, Christopher H., Horita, David A., Thomas, Michael J., Salsbury, Freddie R., Lively, Mark O., Gmeiner, William H.
Publicado em 2014

Prostate-specific membrane antigen-targeted liposomes specifically deliver the Zn(2+) chelator TPEN inducing oxidative stress in prostate cancer cells

Por Stuart, Christopher H, Singh, Ravi, Smith, Thomas L, D’Agostino, Ralph, Caudell, David, Balaji, KC, Gmeiner, William H
Publicado no Nanomedicine (Lond) (2016)

F10 Inhibits Growth of PC3 Xenografts and Enhances the Effects of Radiation Therapy

Por Gmeiner, William H, Willingham, Mark C, Bourland, J Daniel, Hatcher, Heather C, Smith, Thomas L, D'Agostino, Ralph B, Blackstock, William
Publicado no J Clin Oncol Res (2014)