Development of modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity

Therapeutic small interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stability and increase affinity in Watson–Crick base pairing. However, the precise fate of such modified nucleotides once the siRNA is degraded within the cell is unknown. Previously, we de...

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Detaylı Bibliyografya
Asıl Yazarlar: Wu, Shao-yu, Chen, Tian-min, Gmeiner, William H., Chu, Edward, Schmitz, John C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2013
Konular:
RNA
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632118/
https://ncbi.nlm.nih.gov/pubmed/23449220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt120
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