Development of modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity

Therapeutic small interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stability and increase affinity in Watson–Crick base pairing. However, the precise fate of such modified nucleotides once the siRNA is degraded within the cell is unknown. Previously, we de...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wu, Shao-yu, Chen, Tian-min, Gmeiner, William H., Chu, Edward, Schmitz, John C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2013
Gaiak:
RNA
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632118/
https://ncbi.nlm.nih.gov/pubmed/23449220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt120
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