2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity

The synthesis of oligonucleotides containing 2′-deoxy-2′-fluoro-4′-thioarabinonucleotides is described. 2′-Deoxy-2′-fluoro-5-methyl-4′-thioarabinouridine (4′S-FMAU) was incorporated into 18-mer antisense oligonucleotides (AONs). 4′S-FMAU adopts a predominantly northern sugar conformation. Oligonucle...

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Bibliografiske detaljer
Main Authors: Watts, Jonathan K., Choubdar, Niloufar, Sadalapure, Kashinath, Robert, Francis, Wahba, Alexander S., Pelletier, Jerry, Mario Pinto, B., Damha, Masad J.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2007
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1865065/
https://ncbi.nlm.nih.gov/pubmed/17284457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl1153
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