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Development of modified siRNA molecules incorporating 5-fluoro-2′-deoxyuridine residues to enhance cytotoxicity

Therapeutic small interfering RNAs (siRNAs) are composed of chemically modified nucleotides, which enhance RNA stability and increase affinity in Watson–Crick base pairing. However, the precise fate of such modified nucleotides once the siRNA is degraded within the cell is unknown. Previously, we de...

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Bibliografiske detaljer
Main Authors: Wu, Shao-yu, Chen, Tian-min, Gmeiner, William H., Chu, Edward, Schmitz, John C.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
Fag:
RNA
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632118/
https://ncbi.nlm.nih.gov/pubmed/23449220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt120
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