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Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity
Previous studies have indicated that 5-Fluoro-2′-deoxyuridine-5′-O-monophosphate 10mer (FdUMP[10]) displays strong antileukemic activity through the dual targeting of thymidylate synthase (TS) and DNA topoisomerase 1 (Top1). The present studies were undertaken to clarify the relationship between the...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3660094/ https://ncbi.nlm.nih.gov/pubmed/23085462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2012.10.007 |
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