Replication-dependent irreversible topoisomerase 1 poisoning is responsible for FdUMP[10] anti-leukemic activity

Ítems similars

• Unique dual targeting of thymidylate synthase and topoisomerase1 by FdUMP[10] results in high efficacy against AML and low toxicity
  per: Pardee, Timothy S., et al.
  Publicat: (2012)
• Genome-Wide mRNA and microRNA Profiling of the NCI 60 Cell Line Screen and Comparison of FdUMP[10] with fluorouracil, floxuridine, and Top1 Poisons
  per: Gmeiner, William H., et al.
  Publicat: (2010)
• Amino acid sequence at the FdUMP binding site of thymidylate synthetase.
  per: Bellisario, R L, et al.
  Publicat: (1976)
• Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding
  per: Gibson, Lydia M., et al.
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• The poison oligonucleotide F10 is highly effective against acute lymphoblastic leukemia while sparing normal hematopoietic cells
  per: Pardee, Timothy S., et al.
  Publicat: (2014)