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Entrapment of DNA topoisomerase-DNA complexes by nucleotide/nucleoside analogs
Topoisomerases are well-validated targets for cancer chemotherapy and DNA topoisomerase 1 (Top1) is the sole target of the camptothecin (CPT) class of anticancer drugs. Over the last 20 years, multiple studies have shown Top1 activity is modulated by non-native DNA structures and this can lead to tr...
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| Udgivet i: | Cancer Drug Resist |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
OAE Publishing Inc.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6953902/ https://ncbi.nlm.nih.gov/pubmed/31930190 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.20517/cdr.2019.95 |
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