An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

Por Gates, Kent S.
Publicado em 2009

Possible Chemical Mechanisms Underlying the Antitumor Activity of S-Deoxyleinamycin

Por Sivaramakrishnan, Santhosh, Gates, Kent S.
Publicado em 2007

Entering the leinamycin rearrangement via 2-(trimethylsilyl)ethyl sulfoxides

Por Keerthi, Kripa, Gates, Kent S.
Publicado em 2007

Hypoxia-selective, enzymatic conversion of 6-nitroquinoline into a fluorescent helicene: pyrido[3,2-f]quinolino[6,5-c]cinnoline 3-oxide

Por Rajapakse, Anuruddha, Gates, Kent S.
Publicado em 2012

Thiol dependent recovery of catalytic activity from oxidized protein tyrosine phosphatases

Por Parsons, Zachary D., Gates, Kent S.
Publicado em 2013

A Simple, High-Yield Synthesis of DNA Duplexes Containing a Covalent, Thermally-Reversible Interstrand Cross-link At a Defined Location()

Por Varela, Jacqueline Gamboa, Gates, Kent S.
Publicado no Angew Chem Int Ed Engl (2015)

Simple, High-Yield Syntheses of DNA Duplexes Containing Interstrand DNA-DNA Cross-links Between an N(4)-Aminocytidine Residue and an Abasic Site

Por Gamboa Varela, Jacqueline, Gates, Kent S.
Publicado no Curr Protoc Nucleic Acid Chem (2016)

Evidence for a Morin Type Intramolecular Cyclization of an Alkene with a Phenylsulfenic Acid Group in Neutral Aqueous Solution

Por Keerthi, Kripa, Sivaramakrishnan, Santhosh, Gates, Kent S.
Publicado em 2008

Interstrand Crosslinks Generated by Abasic Sites in Duplex DNA

Por Dutta, Sanjay, Chowdhury, Goutam, Gates, Kent S.
Publicado em 2007

Characterization of DNA Damage Induced by a Natural Product Antitumor Antibiotic Leinamycin in Human Cancer Cells

Por Viswesh, Velliyur, Gates, Kent, Sun, Daekyu
Publicado em 2010

Biologically Relevant Chemical Properties of Peroxymonophosphate ((=)O(3)POOH)

Por LaButti, Jason N., Gates, Kent S.
Publicado em 2008

Protection of a single-cysteine redox switch from oxidative destruction: on the functional role of sulfenyl amide formation in the redox-regulated enzyme PTP1B

Por Sivaramakrishnan, Santhosh, Cummings, Andrea H., Gates, Kent S.
Publicado em 2009

Synthesis and Crystal Structure of the Azoxydichinyl Helicene, Pyrido[3,2-f]quinolino[6,5-c]cinnoline 5-Oxide Monohydrate

Por Rajapakse, Anuruddha, Barnes, Charles L., Gates, Kent S.
Publicado em 2011

Initiation of DNA Strand Cleavage by 1,2,4-Benzotriazine 1,4-Dioxide Antitumor Agents: Mechanistic Insight from Studies of 3-Methyl-1,2,4-benzotriazine 1,4-Dioxide

Por Junnotula, Venkatraman, Sarkar, Ujjal, Sinha, Sarmistha, Gates, Kent S.
Publicado em 2009

Electronic Structures and Spin Topologies of γ-Picoliniumyl Radicals. A Study of the Homolysis of N-Methyl-γ-Picolinium and of Benzo-, Dibenzo-, and Naphthoannulated Analogs

Por Glaser, Rainer, Sui, Yongqiang, Sarkar, Ujjal, Gates, Kent S.
Publicado em 2008

Generation of DNA-damaging reactive oxygen species via the autoxidation of hydrogen sulfide under physiologically-relevant conditions: chemistry relevant to both the genotoxic and...

Por Hoffman, Marjorie, Rajapakse, Anuruddha, Shen, Xiulong, Gates, Kent S.
Publicado em 2012

The macrocycle of leinamycin imparts hydrolytic stability to the thiol-sensing 1,2-dithiolan-3-one 1-oxide unit of the natural product

Por Sivaramakrishnan, Santhosh, Breydo, Leonid, Sun, Daekyu, Gates, Kent S.
Publicado em 2012

Synthesis and characterization of a small analogue of the anticancer natural product leinamycin

Por Keerthi, Kripa, Rajapakse, Anuruddha, Sun, Daekyu, Gates, Kent S.
Publicado em 2012

Effective molarity in a nucleic acid-controlled reaction

Por Catalano, Michael J., Price, Nathan E., Gates, Kent S.
Publicado no Bioorg Med Chem Lett (2016)

Kinetics and Mechanism of Protein Tyrosine Phosphatase 1B (PTP1B) Inactivation by Acrolein

Por Seiner, Derrick R., LaButti, Jason N., Gates, Kent S.
Publicado em 2007