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A Simple, High-Yield Synthesis of DNA Duplexes Containing a Covalent, Thermally-Reversible Interstrand Cross-link At a Defined Location()

Interstrand DNA-DNA cross-links are highly toxic to cells because these lesions block the extraction of information from the genetic material. The pathways by which cells repair cross-links are important, but not well understood. The preparation of chemically well-defined cross-linked DNA substrates...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Angew Chem Int Ed Engl
Prif Awduron: Varela, Jacqueline Gamboa, Gates, Kent S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4532324/
https://ncbi.nlm.nih.gov/pubmed/25967397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201502566
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