Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?

Por Freitas-Junior, Lucio H., Chatelain, Eric, Kim, Helena Andrade, Siqueira-Neto, Jair L.
Publicado em 2012

Zika antiviral chemotherapy: identification of drugs and promising starting points for drug discovery from an FDA-approved library

Por Pascoalino, Bruno S., Courtemanche, Gilles, Cordeiro, Marli T., Gil, Laura H. V. G., Freitas-Junior, Lucio
Publicado no F1000Res (2016)

A central role for Plasmodium falciparum subtelomeric regions in spatial positioning and telomere length regulation

Por Figueiredo, Luisa M., Freitas-Junior, Lúcio H., Bottius, Emmanuel, Olivo-Marin, Jean-Christophe, Scherf, Artur
Publicado em 2002

A high-throughput cell-based assay to screen for drugs affecting PfEMP1 transport to RBC surface

Por Ku, Min-Je, Dossin, Fernando M, Hansen, Michael AE, Ma, Minjung, Genovesio, Auguste, Freitas-Junior, Lucio
Publicado em 2011

An Image Analysis Algorithm for Malaria Parasite Stage Classification and Viability Quantification

Por Moon, Seunghyun, Lee, Sukjun, Kim, Heechang, Freitas-Junior, Lucio H., Kang, Myungjoo, Ayong, Lawrence, Hansen, Michael A. E.
Publicado em 2013

Quantum dots: a new tool for anti-malarial drug assays

Por Ku, Min-Je, Dossin, Fernando M, Choi, Youngseon, Moraes, Carolina B, Ryu, Jiyoung, Song, Rita, Freitas-Junior, Lucio H
Publicado em 2011

An Image-Based Drug Susceptibility Assay Targeting the Placental Sequestration of Plasmodium falciparum-Infected Erythrocytes

Por Ku, Min-Je, Dossin, Fernando de M., Hansen, Michael A. E., Genovesio, Auguste, Ayong, Lawrence, Freitas-Junior, Lucio H.
Publicado em 2012

Shortening the drug discovery pipeline: small molecule high content screening for lead discovery in neglected disease

Por Cechetto, Jonathan, Jeon, Hee Kyoung, Jang, Jiyeon, Kwon, Doyoon, Christophe, Thierry, Brodin, Priscille, Yang, Gyongseon, Neto, Jair, Freitas Junior, Lucio
Publicado em 2011

Development of a cell-based high throughput assay system and IN-house image analysis software for screening of active compounds against dengue virus

Por Cruz, Deu John M, Koishi, Andrea C, Pamplona, Ana Luiza M, Genovesio, Auguste, Duarte dos Santos, Claudia N, Freitas-Junior, Lucio
Publicado em 2011

An Image-Based Algorithm for Precise and Accurate High Throughput Assessment of Drug Activity against the Human Parasite Trypanosoma cruzi

Por Moon, Seunghyun, Siqueira-Neto, Jair L., Moraes, Carolina Borsoi, Yang, Gyongseon, Kang, Myungjoo, Freitas-Junior, Lucio H., Hansen, Michael A. E.
Publicado em 2014

Proteomic-Based Approach To Gain Insight into Reprogramming of THP-1 Cells Exposed to Leishmania donovani over an Early Temporal Window

Por Singh, Alok Kumar, Pandey, Rajeev Kumar, Siqueira-Neto, Jair Lage, Kwon, Yong-Jun, Freitas-Junior, Lucio H., Shaha, Chandrima, Madhubala, Rentala
Publicado no Infect Immun (2015)

Transcription Sites Are Developmentally Regulated during the Asexual Cycle of Plasmodium falciparum

Por Moraes, Carolina B., Dorval, Thierry, Contreras-Dominguez, Mónica, Dossin, Fernando de M., Hansen, Michael A. E., Genovesio, Auguste, Freitas-Junior, Lucio H.
Publicado em 2013

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: implications for Chagas disease drug discovery and development

Por Moraes, Carolina B., Giardini, Miriam A., Kim, Hwayoung, Franco, Caio H., Araujo-Junior, Adalberto M., Schenkman, Sergio, Chatelain, Eric, Freitas-Junior, Lucio H.
Publicado em 2014

Open drug discovery for the Zika virus

Por Ekins, Sean, Mietchen, Daniel, Coffee, Megan, Stratton, Thomas P, Freundlich, Joel S, Freitas-Junior, Lucio, Muratov, Eugene, Siqueira-Neto, Jair, Williams, Antony J, Andrade, Carolina
Publicado no F1000Res (2016)

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

Por Siqueira-Neto, Jair L., Moon, Seunghyun, Jang, Jiyeon, Yang, Gyongseon, Lee, Changbok, Moon, Hong Kee, Chatelain, Eric, Genovesio, Auguste, Cechetto, Jonathan, Freitas-Junior, Lucio H.
Publicado em 2012

A genetic screen for improved plasmid segregation reveals a role for Rep20 in the interaction of Plasmodium falciparum chromosomes

Por O’Donnell, Rebecca A., Freitas-Junior, Lúcio H., Preiser, Peter R., Williamson, Donald H., Duraisingh, Manoj, McElwain, Terry F., Scherf, Artur, Cowman, Alan F., Crabb, Brendan S.
Publicado em 2002

Automated Nuclear Analysis of Leishmania major Telomeric Clusters Reveals Changes in Their Organization during the Parasite's Life Cycle

Por Dossin, Fernando de M., Dufour, Alexandre, Dusch, Elodie, Siqueira-Neto, Jair L., Moraes, Carolina B., Yang, Gyong Seon, Cano, Maria Isabel, Genovesio, Auguste, Freitas-Junior, Lucio H.
Publicado em 2008

Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis

Por Zhang, Yonghui, Zhu, Wei, Liu, Yi-Liang, Wang, Hong, Wang, Ke, Li, Kai, No, Joo Hwan, Ayong, Lawrence, Gulati, Anmol, Pang, Ran, Freitas-Junior, Lucio, Morita, Craig T., Oldfield, Eric
Publicado em 2013

Leishmania amazonensis Promastigotes Present Two Distinct Modes of Nucleus and Kinetoplast Segregation during Cell Cycle

Por da Silva, Marcelo Santos, Monteiro, Jomar Patrício, Nunes, Vinícius Santana, Vasconcelos, Elton José, Perez, Arina Marina, Freitas-Júnior, Lúcio de Holanda, Elias, Maria Carolina, Cano, Maria Isabel Nogueira
Publicado em 2013

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

Por No, Joo Hwan, de Macedo Dossin, Fernando, Zhang, Yonghui, Liu, Yi-Liang, Zhu, Wei, Feng, Xinxin, Yoo, Jinyoung Anny, Lee, Eunhae, Wang, Ke, Hui, Raymond, Freitas-Junior, Lucio H., Oldfield, Eric
Publicado em 2012