Multiple Genetic Pathways Involving Amino Acid Position 143 of HIV-1 Integrase Are Preferentially Associated with Specific Secondary Amino Acid Substitutions and Confer Resistance...

Por Huang, Wei, Frantzell, Arne, Fransen, Signe, Petropoulos, Christos J.
Publicado em 2013

Substitutions at Amino Acid Positions 143, 148, and 155 of HIV-1 Integrase Define Distinct Genetic Barriers to Raltegravir Resistance In Vivo

Por Fransen, Signe, Gupta, Soumi, Frantzell, Arne, Petropoulos, Christos J., Huang, Wei
Publicado em 2012

Longitudinal Analysis of Raltegravir Susceptibility and Integrase Replication Capacity of Human Immunodeficiency Virus Type 1 during Virologic Failure

Por Fransen, Signe, Karmochkine, Marina, Huang, Wei, Weiss, Laurence, Petropoulos, Christos J., Charpentier, Charlotte
Publicado em 2009

Combinations of Mutations in the Connection Domain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Assessing the Impact on Nucleoside and Nonnucleoside Reverse Transc...

Por Gupta, Soumi, Fransen, Signe, Paxinos, Ellen E., Stawiski, Eric, Huang, Wei, Petropoulos, Christos J.
Publicado em 2010

Mutational Pathways and Genetic Barriers to CXCR4-Mediated Entry by Human Immunodeficiency Virus Type 1

Por Huang, Wei, Frantzell, Arne, Toma, Jonathan, Fransen, Signe, Whitcomb, Jeannette M., Stawiski, Eric, Petropoulos, Christos J.
Publicado em 2010

Loss of Raltegravir Susceptibility by Human Immunodeficiency Virus Type 1 Is Conferred via Multiple Nonoverlapping Genetic Pathways

Por Fransen, Signe, Gupta, Soumi, Danovich, Robert, Hazuda, Daria, Miller, Michael, Witmer, Marc, Petropoulos, Christos J., Huang, Wei
Publicado em 2009

Performance of the Abbott RealTime HIV-1 Viral Load Assay Is Not Impacted by Integrase Inhibitor Resistance-Associated Mutations

Por Young, Thomas P., Cloherty, Gavin, Fransen, Signe, Napolitano, Laura, Swanson, Priscilla, Herman, Christine, Parkin, Neil T., Hackett, John
Publicado em 2011

Suppression of Dualtropic Human Immunodeficiency Virus Type 1 by the CXCR4 Antagonist AMD3100 Is Associated with Efficiency of CXCR4 Use and Baseline Virus Composition

Por Fransen, Signe, Bridger, Gary, Whitcomb, Jeannette M., Toma, Jonathan, Stawiski, Eric, Parkin, Neil, Petropoulos, Christos J., Huang, Wei
Publicado em 2008

Coreceptor Tropism Can Be Influenced by Amino Acid Substitutions in the gp41 Transmembrane Subunit of Human Immunodeficiency Virus Type 1 Envelope Protein

Por Huang, Wei, Toma, Jonathan, Fransen, Signe, Stawiski, Eric, Reeves, Jacqueline D., Whitcomb, Jeannette M., Parkin, Neil, Petropoulos, Christos J.
Publicado em 2008

Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy

Por Hatano, Hiroyu, Lampiris, Harry, Fransen, Signe, Gupta, Soumi, Huang, Wei, Hoh, Rebecca, Martin, Jeffrey N., Lalezari, Jacob, Bangsberg, David, Petropoulos, Christos, Deeks, Steven G.
Publicado em 2010

Development and Characterization of a Novel Single-Cycle Recombinant-Virus Assay To Determine Human Immunodeficiency Virus Type 1 Coreceptor Tropism

Por Whitcomb, Jeannette M., Huang, Wei, Fransen, Signe, Limoli, Kay, Toma, Jonathan, Wrin, Terri, Chappey, Colombe, Kiss, Linda D. B., Paxinos, Ellen E., Petropoulos, Christos J.
Publicado em 2007

Connection Domain Mutations in HIV-1 Reverse Transcriptase Do Not Impact Etravirine Susceptibility and Virologic Responses to Etravirine-Containing Regimens

Por Gupta, Soumi, Vingerhoets, Johan, Fransen, Signe, Tambuyzer, Lotke, Azijn, Hilde, Frantzell, Arne, Paredes, Roger, Coakley, Eoin, Nijs, Steven, Clotet, Bonaventura, Petropoulos, Christos J., Schapiro, Jonathan, Huang, Wei, Picchio, Gaston
Publicado em 2011

Characterization of Human Immunodeficiency Virus Type 1 Populations Containing CXCR4-Using Variants from Recently Infected Individuals

Por Huang, Wei, Toma, Jonathan, Stawiski, Eric, Fransen, Signe, Wrin, Terri, Parkin, Neil, Whitcomb, Jeannette M., Coakley, Eoin, Hecht, Frederick M., Deeks, Steven G., Gandhi, Rajesh T., Eshleman, Susan H., Petropoulos, Christos J.
Publicado em 2009

Coreceptor Tropism in Human Immunodeficiency Virus Type 1 Subtype D: High Prevalence of CXCR4 Tropism and Heterogeneous Composition of Viral Populations

Por Huang, Wei, Eshleman, Susan H., Toma, Jonathan, Fransen, Signe, Stawiski, Eric, Paxinos, Ellen E., Whitcomb, Jeannette M., Young, Alicia M., Donnell, Deborah, Mmiro, Francis, Musoke, Philippa, Guay, Laura A., Jackson, J. Brooks, Parkin, Neil T., Petropoulos, Christos J.
Publicado em 2007

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

Por Wan, Nathan, Weinberg, David, Liu, Tzu-Yu, Niehaus, Katherine, Ariazi, Eric A., Delubac, Daniel, Kannan, Ajay, White, Brandon, Bailey, Mitch, Bertin, Marvin, Boley, Nathan, Bowen, Derek, Cregg, James, Drake, Adam M., Ennis, Riley, Fransen, Signe, Gafni, Erik, Hansen, Loren, Liu, Yaping, Otte, Gabriel L., Pecson, Jennifer, Rice, Brandon, Sanderson, Gabriel E., Sharma, Aarushi, St. John, John, Tang, Catherina, Tzou, Abraham, Young, Leilani, Putcha, Girish, Haque, Imran S.
Publicado no BMC Cancer (2019)