Suppression of Dualtropic Human Immunodeficiency Virus Type 1 by the CXCR4 Antagonist AMD3100 Is Associated with Efficiency of CXCR4 Use and Baseline Virus Composition

In a phase I/II evaluation of the CXCR4 antagonist AMD3100, human immunodeficiency virus RNA levels were significantly reduced in a single study subject who harbored CXCR4 (X4)-tropic virus, but not in subjects who harbored either dual/mixed (DM)-tropic or CCR5 (R5)-tropic virus (C. W. Hendrix et al...

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Bibliografiska uppgifter
Huvudupphovsmän: Fransen, Signe, Bridger, Gary, Whitcomb, Jeannette M., Toma, Jonathan, Stawiski, Eric, Parkin, Neil, Petropoulos, Christos J., Huang, Wei
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2008
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443920/
https://ncbi.nlm.nih.gov/pubmed/18443125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01226-07
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