Baseline Resistance of Primary Human Immunodeficiency Virus Type 1 Strains to the CXCR4 Inhibitor AMD3100

We screened a panel of R5X4 and X4 human immunodeficiency virus type 1 (HIV-1) strains for their sensitivities to AMD3100, a small-molecule CXCR4 antagonist that blocks HIV-1 infection via this coreceptor. While no longer under clinical development, AMD3100 is a useful tool with which to probe inter...

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Autori principali: Harrison, Jessamina E., Lynch, Jonathan B., Sierra, Luz-Jeannette, Blackburn, Leslie A., Ray, Neelanjana, Collman, Ronald G., Doms, Robert W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2583649/
https://ncbi.nlm.nih.gov/pubmed/18799588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01303-08
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