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HR-2 Mutations in Human Immunodeficiency Virus Type 1 gp41 Restore Fusion Kinetics Delayed by HR-1 Mutations That Cause Clinical Resistance to Enfuvirtide

Enfuvirtide (ENF) prevents the entry of human immunodeficiency virus type 1 (HIV-1) into cells by binding to the HR-1 region of the viral envelope (Env) protein gp41 subunit. Resistance to ENF arises via mutations in the drug binding site in HR-1. In addition, HR-2 mutations are commonly observed in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Ray, Neelanjana, Blackburn, Leslie A., Doms, Robert W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2655552/
https://ncbi.nlm.nih.gov/pubmed/19153234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02496-08
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