Mutational Pathways and Genetic Barriers to CXCR4-Mediated Entry by Human Immunodeficiency Virus Type 1

To examine mutational pathways that lead to CXCR4 use of HIV-1, we analyzed the genotypic and phenotypic characteristics of envelope sequences from a large panel of patient virus populations and individual clones containing different V3 mutations. Basic amino acid substitutions at position 11 were s...

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Hauptverfasser: Huang, Wei, Frantzell, Arne, Toma, Jonathan, Fransen, Signe, Whitcomb, Jeannette M., Stawiski, Eric, Petropoulos, Christos J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3428208/
https://ncbi.nlm.nih.gov/pubmed/21071054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2010.09.026
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