Connection Domain Mutations in HIV-1 Reverse Transcriptase Do Not Impact Etravirine Susceptibility and Virologic Responses to Etravirine-Containing Regimens

Connection domain mutations (CDMs) in HIV-1 reverse transcriptase (RT) alter susceptibility to some nucleoside/nonnucleoside RT inhibitors (NRTIs/NNRTIs). Their effects on susceptibility and virologic responses to etravirine were analyzed. Seventeen CDMs were evaluated: L283I, E312Q, G333D, G333E, G...

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Hauptverfasser: Gupta, Soumi, Vingerhoets, Johan, Fransen, Signe, Tambuyzer, Lotke, Azijn, Hilde, Frantzell, Arne, Paredes, Roger, Coakley, Eoin, Nijs, Steven, Clotet, Bonaventura, Petropoulos, Christos J., Schapiro, Jonathan, Huang, Wei, Picchio, Gaston
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101386/
https://ncbi.nlm.nih.gov/pubmed/21464253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01695-10
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