A protein phosphatase functions to recycle RNA polymerase II

por Cho, Helen, Kim, Tae-Kyung, Mancebo, Helena, Lane, William S., Flores, Osvaldo, Reinberg, Danny
Publicado 1999

Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication

por Flores, Osvaldo, Lee, Gary, Kessler, Joseph, Miller, Michael, Schlief, William, Tomassini, Joanne, Hazuda, Daria
Publicado 1999

Characterization of a Novel Small Molecule Subtype Specific Estrogen-Related Receptor α Antagonist in MCF-7 Breast Cancer Cells

por Chisamore, Michael J., Cunningham, Michael E., Flores, Osvaldo, Wilkinson, Hilary A., Chen, J. Don
Publicado 2009

Persistent Replication of Hepatitis C Virus Replicons Expressing the β-Lactamase Reporter in Subpopulations of Highly Permissive Huh7 Cells

por Murray, Edward M., Grobler, Jay A., Markel, Eric J., Pagnoni, Marco F., Paonessa, Giacomo, Simon, Adam J., Flores, Osvaldo A.
Publicado 2003

Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants

por Lam, Angela M., Ren, Suping, Espiritu, Christine, Kelly, Mollie, Lau, Vincent, Zheng, Lingjie, Hartman, George D., Flores, Osvaldo A., Klumpp, Klaus
Publicado en Antimicrob Agents Chemother (2017)

Non-invasive muscle contraction assay to study rodent models of sarcopenia

por Chiu, Chi-Sung, Weber, Hans, Adamski, Sharon, Rauch, Albert, Gentile, Michael A, Alves, Stephen E, Kath, Gary, Flores, Osvaldo, Wilkinson, Hilary A
Publicado 2011

P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

por Mancebo, Helena S.Y., Lee, Gary, Flygare, John, Tomassini, Joanne, Luu, Percy, Zhu, Yuerong, Peng, Junmin, Blau, Carol, Hazuda, Daria, Price, David, Flores, Osvaldo
Publicado 1997

Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus

por Lam, Angela M., Espiritu, Christine, Vogel, Robert, Ren, Suping, Lau, Vincent, Kelly, Mollie, Kuduk, Scott D., Hartman, George D., Flores, Osvaldo A., Klumpp, Klaus
Publicado en Antimicrob Agents Chemother (2018)

High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

por Klumpp, Klaus, Lam, Angela M., Lukacs, Christine, Vogel, Robert, Ren, Suping, Espiritu, Christine, Baydo, Ruth, Atkins, Kateri, Abendroth, Jan, Liao, Guochun, Efimov, Andrey, Hartman, George, Flores, Osvaldo A.
Publicado en Proc Natl Acad Sci U S A (2015)

Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay

por Ludmerer, Steven W., Graham, Donald J., Boots, Evelyn, Murray, Edward M., Simcoe, Amy, Markel, Eric J., Grobler, Jay A., Flores, Osvaldo A., Olsen, David B., Hazuda, Daria J., LaFemina, Robert L.
Publicado 2005

Inhibitory Effect of 2′-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells

por Tomassini, Joanne E., Getty, Krista, Stahlhut, Mark W., Shim, Sung, Bhat, Balkrishen, Eldrup, Anne B., Prakash, Thazha P., Carroll, Steven S., Flores, Osvaldo, MacCoss, Malcolm, McMasters, Daniel R., Migliaccio, Giovanni, Olsen, David B.
Publicado 2005

Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in Vivo

por Glantschnig, Helmut, Hampton, Richard A., Lu, Ping, Zhao, Jing Z., Vitelli, Salvatore, Huang, Lingyi, Haytko, Peter, Cusick, Tara, Ireland, Cheryl, Jarantow, Stephen W., Ernst, Robin, Wei, Nan, Nantermet, Pascale, Scott, Kevin R., Fisher, John E., Talamo, Fabio, Orsatti, Laura, Reszka, Alfred A., Sandhu, Punam, Kimmel, Donald, Flores, Osvaldo, Strohl, William, An, Zhiqiang, Wang, Fubao
Publicado 2010

A 7-Deaza-Adenosine Analog Is a Potent and Selective Inhibitor of Hepatitis C Virus Replication with Excellent Pharmacokinetic Properties

por Olsen, David B., Eldrup, Anne B., Bartholomew, Linda, Bhat, Balkrishen, Bosserman, Michele R., Ceccacci, Alessandra, Colwell, Lawrence F., Fay, John F., Flores, Osvaldo A., Getty, Krista L., Grobler, Jay A., LaFemina, Robert L., Markel, Eric J., Migliaccio, Giovanni, Prhavc, Marija, Stahlhut, Mark W., Tomassini, Joanne E., MacCoss, Malcolm, Hazuda, Daria J., Carroll, Steven S.
Publicado 2004