P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

To identify novel inhibitors of transcriptional activation by the HIV Tat protein, we used a combination of in vitro and in vivo Tat-dependent transcription assays to screen >100,000 compounds. All compounds identified blocked Tat-dependent stimulation of transcriptional elongation. Analysis of a...

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Detalhes bibliográficos
Main Authors: Mancebo, Helena S.Y., Lee, Gary, Flygare, John, Tomassini, Joanne, Luu, Percy, Zhu, Yuerong, Peng, Junmin, Blau, Carol, Hazuda, Daria, Price, David, Flores, Osvaldo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1997
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC316604/
https://ncbi.nlm.nih.gov/pubmed/9334326
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