P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro

To identify novel inhibitors of transcriptional activation by the HIV Tat protein, we used a combination of in vitro and in vivo Tat-dependent transcription assays to screen >100,000 compounds. All compounds identified blocked Tat-dependent stimulation of transcriptional elongation. Analysis of a pa...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Mancebo, Helena S.Y., Lee, Gary, Flygare, John, Tomassini, Joanne, Luu, Percy, Zhu, Yuerong, Peng, Junmin, Blau, Carol, Hazuda, Daria, Price, David, Flores, Osvaldo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 1997
Assuntos:	Research Paper
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC316604/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9334326/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.11.20.2633
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