Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay

The innate genetic variability characteristic of chronic hepatitis C virus (HCV) infection makes drug resistance a concern in the clinical development of HCV inhibitors. To address this, a transient replication assay was developed to evaluate the replication fitness and the drug sensitivity of NS5B...

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Bibliographische Detailangaben
Hauptverfasser: Ludmerer, Steven W., Graham, Donald J., Boots, Evelyn, Murray, Edward M., Simcoe, Amy, Markel, Eric J., Grobler, Jay A., Flores, Osvaldo A., Olsen, David B., Hazuda, Daria J., LaFemina, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087645/
https://ncbi.nlm.nih.gov/pubmed/15855532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.2059-2069.2005
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