Replication Fitness and NS5B Drug Sensitivity of Diverse Hepatitis C Virus Isolates Characterized by Using a Transient Replication Assay

The innate genetic variability characteristic of chronic hepatitis C virus (HCV) infection makes drug resistance a concern in the clinical development of HCV inhibitors. To address this, a transient replication assay was developed to evaluate the replication fitness and the drug sensitivity of NS5B...

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Detalhes bibliográficos
Main Authors: Ludmerer, Steven W., Graham, Donald J., Boots, Evelyn, Murray, Edward M., Simcoe, Amy, Markel, Eric J., Grobler, Jay A., Flores, Osvaldo A., Olsen, David B., Hazuda, Daria J., LaFemina, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087645/
https://ncbi.nlm.nih.gov/pubmed/15855532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.2059-2069.2005
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