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Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

Polyamines, which are small positively charge molecules present in all cells, play important roles in the replication of DNA and RNA viruses. Chikungunya virus (CHIKV) relies on polyamines for translation of the viral genome upon viral entry, and pharmacological depletion of polyamines limits viral...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Mounce, Bryan C., Cesaro, Teresa, Vlajnić, Lea, Vidiņa, Anna, Vallet, Thomas, Weger-Lucarelli, James, Passoni, Gabriella, Stapleford, Kenneth A., Levraud, Jean-Pierre, Vignuzzi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512238/
https://ncbi.nlm.nih.gov/pubmed/28539441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00344-17
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