Chikungunya Virus Overcomes Polyamine Depletion by Mutation of nsP1 and the Opal Stop Codon To Confer Enhanced Replication and Fitness

Polyamines, which are small positively charge molecules present in all cells, play important roles in the replication of DNA and RNA viruses. Chikungunya virus (CHIKV) relies on polyamines for translation of the viral genome upon viral entry, and pharmacological depletion of polyamines limits viral...

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Veröffentlicht in:J Virol
Hauptverfasser: Mounce, Bryan C., Cesaro, Teresa, Vlajnić, Lea, Vidiņa, Anna, Vallet, Thomas, Weger-Lucarelli, James, Passoni, Gabriella, Stapleford, Kenneth A., Levraud, Jean-Pierre, Vignuzzi, Marco
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512238/
https://ncbi.nlm.nih.gov/pubmed/28539441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00344-17
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