An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration

di Flores, Brittany N., Li, Xingli, Malik, Ahmed M., Martinez, Jose, Beg, Asim A., Barmada, Sami J.
Pubblicato in Cell Rep (2019)

The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

di He, Fang, Flores, Brittany N., Krans, Amy, Frazer, Michelle, Natla, Sam, Niraula, Sarjina, Adefioye, Olamide, Barmada, Sami J., Todd, Peter K.
Pubblicato in Acta Neuropathol Commun (2020)

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity

di Flores, Brittany N., Dulchavsky, Mark E., Krans, Amy, Sawaya, Michael R., Paulson, Henry L., Todd, Peter K., Barmada, Sami J., Ivanova, Magdalena I.
Pubblicato in PLoS One (2016)

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

di Green, Katelyn M., Glineburg, M. Rebecca, Kearse, Michael G., Flores, Brittany N., Linsalata, Alexander E., Fedak, Stephen J., Goldstrohm, Aaron C., Barmada, Sami J., Todd, Peter K.
Pubblicato in Nat Commun (2017)

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

di Green, Katelyn M., Sheth, Udit J., Flores, Brittany N., Wright, Shannon E., Sutter, Alexandra B., Kearse, Michael G., Barmada, Sami J., Ivanova, Magdalena I., Todd, Peter K.
Pubblicato in J Biol Chem (2019)

DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation

di Linsalata, Alexander E, He, Fang, Malik, Ahmed M, Glineburg, Mary Rebecca, Green, Katelyn M, Natla, Sam, Flores, Brittany N, Krans, Amy, Archbold, Hilary C, Fedak, Stephen J, Barmada, Sami J, Todd, Peter K
Pubblicato in EMBO Rep (2019)

A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis

di Rodriguez, Caitlin M., Wright, Shannon E., Kearse, Michael G., Haenfler, Jill M., Flores, Brittany N., Liu, Yu, Ifrim, Marius F., Glineburg, Mary R., Krans, Amy, Jafar-Nejad, Paymaan, Sutton, Michael A., Bassell, Gary J., Parent, Jack M., Rigo, Frank, Barmada, Sami J., Todd, Peter K.
Pubblicato in Nat Neurosci (2020)

Exome sequence analysis suggests genetic burden contributes to phenotypic variability and complex neuropathy

di Gonzaga-Jauregui, Claudia, Harel, Tamar, Gambin, Tomasz, Kousi, Maria, Griffin, Laurie B., Francescatto, Ludmila, Ozes, Burcak, Karaca, Ender, Jhangiani, Shalini, Bainbridge, Matthew N., Lawson, Kim S., Pehlivan, Davut, Okamoto, Yuji, Withers, Marjorie, Mancias, Pedro, Slavotinek, Anne, Reitnauer, Pamela J, Goksungur, Meryem T., Shy, Michael, Crawford, Thomas O., Koenig, Michel, Willer, Jason, Flores, Brittany N., Pediaditrakis, Igor, Us, Onder, Wiszniewski, Wojciech, Parman, Yesim, Antonellis, Anthony, Muzny, Donna M., Katsanis, Nicholas, Battaloglu, Esra, Boerwinkle, Eric, Gibbs, Richard A., Lupski, James R.
Pubblicato in Cell Rep (2015)