An Intramolecular Salt Bridge Linking TDP43 RNA Binding, Protein Stability, and TDP43-Dependent Neurodegeneration

per Flores, Brittany N., Li, Xingli, Malik, Ahmed M., Martinez, Jose, Beg, Asim A., Barmada, Sami J.
Publicat a Cell Rep (2019)

The carboxyl termini of RAN translated GGGGCC nucleotide repeat expansions modulate toxicity in models of ALS/FTD

per He, Fang, Flores, Brittany N., Krans, Amy, Frazer, Michelle, Natla, Sam, Niraula, Sarjina, Adefioye, Olamide, Barmada, Sami J., Todd, Peter K.
Publicat a Acta Neuropathol Commun (2020)

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity

per Flores, Brittany N., Dulchavsky, Mark E., Krans, Amy, Sawaya, Michael R., Paulson, Henry L., Todd, Peter K., Barmada, Sami J., Ivanova, Magdalena I.
Publicat a PLoS One (2016)

RAN translation at C9orf72-associated repeat expansions is selectively enhanced by the integrated stress response

per Green, Katelyn M., Glineburg, M. Rebecca, Kearse, Michael G., Flores, Brittany N., Linsalata, Alexander E., Fedak, Stephen J., Goldstrohm, Aaron C., Barmada, Sami J., Todd, Peter K.
Publicat a Nat Commun (2017)

High-throughput screening yields several small-molecule inhibitors of repeat-associated non-AUG translation

per Green, Katelyn M., Sheth, Udit J., Flores, Brittany N., Wright, Shannon E., Sutter, Alexandra B., Kearse, Michael G., Barmada, Sami J., Ivanova, Magdalena I., Todd, Peter K.
Publicat a J Biol Chem (2019)

DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation

per Linsalata, Alexander E, He, Fang, Malik, Ahmed M, Glineburg, Mary Rebecca, Green, Katelyn M, Natla, Sam, Flores, Brittany N, Krans, Amy, Archbold, Hilary C, Fedak, Stephen J, Barmada, Sami J, Todd, Peter K
Publicat a EMBO Rep (2019)

A native function for RAN translation and CGG repeats in regulating Fragile X protein synthesis

per Rodriguez, Caitlin M., Wright, Shannon E., Kearse, Michael G., Haenfler, Jill M., Flores, Brittany N., Liu, Yu, Ifrim, Marius F., Glineburg, Mary R., Krans, Amy, Jafar-Nejad, Paymaan, Sutton, Michael A., Bassell, Gary J., Parent, Jack M., Rigo, Frank, Barmada, Sami J., Todd, Peter K.
Publicat a Nat Neurosci (2020)

Exome sequence analysis suggests genetic burden contributes to phenotypic variability and complex neuropathy

per Gonzaga-Jauregui, Claudia, Harel, Tamar, Gambin, Tomasz, Kousi, Maria, Griffin, Laurie B., Francescatto, Ludmila, Ozes, Burcak, Karaca, Ender, Jhangiani, Shalini, Bainbridge, Matthew N., Lawson, Kim S., Pehlivan, Davut, Okamoto, Yuji, Withers, Marjorie, Mancias, Pedro, Slavotinek, Anne, Reitnauer, Pamela J, Goksungur, Meryem T., Shy, Michael, Crawford, Thomas O., Koenig, Michel, Willer, Jason, Flores, Brittany N., Pediaditrakis, Igor, Us, Onder, Wiszniewski, Wojciech, Parman, Yesim, Antonellis, Anthony, Muzny, Donna M., Katsanis, Nicholas, Battaloglu, Esra, Boerwinkle, Eric, Gibbs, Richard A., Lupski, James R.
Publicat a Cell Rep (2015)