Neuron loss in the 5XFAD mouse model of Alzheimer’s disease correlates with intraneuronal Aβ(42) accumulation and Caspase-3 activation

Por Eimer, William A, Vassar, Robert
Publicado em 2013

Specificity of Toll-Like Receptor 2 and Dectin-1 Signaling in CNS Macrophages

Por Vijaya Kumar, Deepak Kumar, Eimer, William A., Ramakrishnan, Sreejith
Publicado no J Neurosci (2015)

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Por Rajapaksha, Tharinda W, Eimer, William A, Bozza, Thomas C, Vassar, Robert
Publicado em 2011

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

Por Sadleir, Katherine R, Eimer, William A, Cole, Sarah L, Vassar, Robert
Publicado no Mol Neurodegener (2015)

Genetic Inhibition of Phosphorylation of the Translation Initiation Factor eIF2α Does Not Block Aβ-Dependent Elevation of BACE1 and APP Levels or Reduce Amyloid Pathology in a Mous...

Por Sadleir, Katherine R., Eimer, William A., Kaufman, Randal J., Osten, Pavel, Vassar, Robert
Publicado em 2014

Alzheimer's disease: the potential therapeutic role of the natural antibiotic amyloid-β peptide

Por Kumar, Deepak Kumar Vijaya, Eimer, William A, Tanzi, Rudolph E, Moir, Robert D
Publicado no Neurodegener Dis Manag (2016)

β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects

Por Hitt, Brian, Riordan, Sean M., Kukreja, Lokesh, Eimer, William A., Rajapaksha, Tharinda W., Vassar, Robert
Publicado em 2012

The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

Por Kandalepas, Patty C., Sadleir, Katherine R., Eimer, William A., Zhao, Jie, Nicholson, Daniel A., Vassar, Robert
Publicado em 2013

Erratum to: The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques

Por Kandalepas, Patty C., Sadleir, Katherine R., Eimer, William A., Zhao, Jie, Nicholson, Daniel A., Vassar, Robert
Publicado em 2013

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

Por Eimer, William A., Vijaya Kumar, Deepak Kumar, Shanmugam, Nanda Kumar N., Rodriguez, Alex S., Mitchell, Teryn, Washicosky, Kevin J., György, Bence, Breakefield, Xandra O., Tanzi, Rudolph E., Moir, Robert D.
Publicado no Neuron (2018)

Amyloid-β Peptide Protects Against Microbial Infection In Mouse and Worm Models of Alzheimer’s Disease

Por Vijaya Kumar, Deepak Kumar, Choi, Se Hoon, Washicosky, Kevin J., Eimer, William A., Tucker, Stephanie, Ghofrani, Jessica, Lefkowitz, Aaron, McColl, Gawain, Goldstein, Lee E., Tanzi, Rudolph E., Moir, Robert D.
Publicado no Sci Transl Med (2016)

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

Por Youmans, Katherine L., Tai, Leon M., Nwabuisi-Heath, Evelyn, Jungbauer, Lisa, Kanekiyo, Takahisa, Gan, Ming, Kim, Jungsu, Eimer, William A., Estus, Steve, Rebeck, G. William, Weeber, Edwin J., Bu, Guojun, Yu, Chunjiang, LaDu, Mary Jo
Publicado em 2012

Mutant Allele-Specific CRISPR Disruption in DYT1 Dystonia Fibroblasts Restores Cell Function

Por Cruz, Lilian, György, Bence, Cheah, Pike See, Kleinstiver, Benjamin P., Eimer, William A., Garcia, Sara P., Sharma, Nutan, Ozelius, Laurie J., Bragg, D. Cristopher, Joung, J. Keith, Norberto de Souza, Osmar, Macedo Timmers, Luis Fernando Saraiva, Breakefield, Xandra O.
Publicado no Mol Ther Nucleic Acids (2020)

Intraneuronal Aβ detection in 5xFAD mice by a new Aβ-specific antibody

Por Youmans, Katherine L, Tai, Leon M, Kanekiyo, Takahisa, Stine, W Blaine, Michon, Sara-Claude, Nwabuisi-Heath, Evelyn, Manelli, Arlene M, Fu, Yifan, Riordan, Sean, Eimer, William A, Binder, Lester, Bu, Guojun, Yu, Chunjiang, Hartley, Dean M, LaDu, Mary Jo
Publicado em 2012

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

Por O’Connor, Tracy, Doherty-Sadleir, Katherine R., Maus, Erika, Velliquette, Rodney A., Zhao, Jie, Cole, Sarah L., Eimer, William A., Hitt, Brian, Bembinster, Leslie A., Lammich, Sven, Lichtenthaler, Stefan F., Hébert, Sébastien S., De Strooper, Bart, Haass, Christian, Bennett, David A., Vassar, Robert
Publicado em 2008