Amyloid-β Peptide Protects Against Microbial Infection In Mouse and Worm Models of Alzheimer’s Disease

The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We present in vivo data showing Aβ expression protects against fungal and bacterial infections in mouse, nematode, and cell...

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Bibliografiska uppgifter
I publikationen:Sci Transl Med
Huvudupphovsmän: Vijaya Kumar, Deepak Kumar, Choi, Se Hoon, Washicosky, Kevin J., Eimer, William A., Tucker, Stephanie, Ghofrani, Jessica, Lefkowitz, Aaron, McColl, Gawain, Goldstein, Lee E., Tanzi, Rudolph E., Moir, Robert D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505565/
https://ncbi.nlm.nih.gov/pubmed/27225182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf1059
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