טוען...
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level
BACKGROUND: The β-secretase, BACE1, cleaves APP to initiate generation of the β-amyloid peptide, Aβ, that comprises amyloid plaques in Alzheimer’s disease (AD). Reducing BACE1 activity is an attractive therapeutic approach to AD, but complete inhibition of BACE1 could have mechanism-based side-effec...
שמור ב:
| הוצא לאור ב: | Mol Neurodegener |
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| Main Authors: | , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
BioMed Central
2015
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4297413/ https://ncbi.nlm.nih.gov/pubmed/25567526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-10-1 |
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