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BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mic
Evidence suggests that β-amyloid (Aβ) peptide triggers a pathogenic cascade leading to neuronal loss in Alzheimer’s disease (AD). However, the causal link between Aβ and neuron death in vivo remains unclear since most animal models fail to recapitulate the dramatic cell loss observed in AD. We have...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2006
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1876698/ https://ncbi.nlm.nih.gov/pubmed/17258906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2006.12.008 |
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