Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition

Por Ambele, Melvin A, Egan, Timothy J
Publicado em 2012

Differential Effects of Quinoline Antimalarials on Endocytosis in Plasmodium falciparum

Por Roberts, Lindi, Egan, Timothy J., Joiner, Keith A., Hoppe, Heinrich C.
Publicado em 2008

The single crystal X-ray structure of β-hematin DMSO solvate grown in the presence of chloroquine, a β-hematin growth-rate inhibitor

Por Gildenhuys, Johandie, le Roex, Tanya, Egan, Timothy J., de Villiers, Katherine A.
Publicado em 2013

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity

Por Wicht, Kathryn J., Combrinck, Jill M., Smith, Peter J., Egan, Timothy J.
Publicado no Bioorg Med Chem (2014)

Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone–Chloroquine Hybrids

Por Andayi, Warren A., Egan, Timothy J., Gut, Jiri, Rosenthal, Philip J., Chibale, Kelly
Publicado em 2013

Increase on the Initial Soluble Heme Levels in Acidic Conditions Is an Important Mechanism for Spontaneous Heme Crystallization In Vitro

Por Stiebler, Renata, Hoang, Anh N., Egan, Timothy J., Wright, David W., Oliveira, Marcus F.
Publicado em 2010

The Neutral Lipid Composition Present in the Digestive Vacuole of Plasmodium falciparum Concentrates Heme and Mediates β-Hematin Formation with an Unusually Low Activation Energy

Por Hoang, Anh N., Sandlin, Rebecca D., Omar, Aneesa, Egan, Timothy J., Wright, David W.
Publicado em 2010

identification and SAR evaluation of hemozoin-inhibiting benzamides active against Plasmodium falciparum

Por Wicht, Kathryn J., Combrinck, Jill M., Smith, Peter J., Hunter, Roger, Egan, Timothy J.
Publicado no J Med Chem (2016)

Effects of N-glycosylation of the human cation channel TRPA1 on agonist-sensitivity

Por Egan, Timothy J., Acuña, Mario A., Zenobi-Wong, Marcy, Zeilhofer, Hanns Ulrich, Urech, David
Publicado no Biosci Rep (2016)

Novel multispecific heterodimeric antibody format allowing modular assembly of variable domain fragments

Por Egan, Timothy J., Diem, Dania, Weldon, Richard, Neumann, Tessa, Meyer, Sebastian, Urech, David M.
Publicado no MAbs (2016)

Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum

Por Wicht, Kathryn J., Combrinck, Jill M., Smith, Peter J., Hunter, Roger, Egan, Timothy J.
Publicado no ACS Med Chem Lett (2017)

Synthetic Hemozoin (β-Hematin) Crystals Nucleate at the Surface of Neutral Lipid Droplets that Control Their Sizes

Por Ambele, Melvin A., Sewell, B. Trevor, Cummings, Franscious R., Smith, Peter J., Egan, Timothy J.
Publicado em 2013

CRYSTALLIZATION OF SYNTHETIC HAEMOZOIN (β-HAEMATIN) NUCLEATED AT THE SURFACE OF LIPID PARTICLES

Por Hoang, Anh N., Ncokazi, Kanyile K., de Villiers, Katherine A., Wright, David W., Egan, Timothy J.
Publicado em 2009

Optimization of a multi-well colorimetric assay to determine haem species in Plasmodium falciparum in the presence of anti-malarials

Por Combrinck, Jill M., Fong, Kim Y., Gibhard, Liezl, Smith, Peter J., Wright, David W., Egan, Timothy J.
Publicado no Malar J (2015)

Unsaturated Glycerophospholipids Mediate Heme Crystallization: Biological Implications for Hemozoin Formation in the Kissing Bug Rhodnius prolixus

Por Stiebler, Renata, Majerowicz, David, Knudsen, Jens, Gondim, Katia C., Wright, David W., Egan, Timothy J., Oliveira, Marcus F.
Publicado em 2014

Identification of β-hematin inhibitors in a high-throughput screening effort reveals scaffolds with in vitro antimalarial activity

Por Sandlin, Rebecca D., Fong, Kim Y., Wicht, Kathryn J., Carrell, Holly M., Egan, Timothy J., Wright, David W.
Publicado no Int J Parasitol Drugs Drug Resist (2014)

Enone- and chalcone-chloroquinoline hybrid analogs: In silico-guided design, synthesis, antiplasmodial activity, in vitro metabolism and mechanistic studies

Por Guantai, Eric M., Ncokazi, Kanyile, Egan, Timothy J., Gut, Jiri, Rosenthal, Philip J., Bhampidipati, Ravi, Kopinathan, Anitha, Smith, Peter J., Chibale, Kelly
Publicado em 2011

Insights into the Role of Heme in the Mechanism of Action of Antimalarials

Por Combrinck, Jill M., Mabotha, Tebogo E., Ncokazi, Kanyile K., Ambele, Melvin A., Taylor, Dale, Smith, Peter J., Hoppe, Heinrich C., Egan, Timothy J.
Publicado em 2012

Fate of haem iron in the malaria parasite Plasmodium falciparum.

Por Egan, Timothy J, Combrinck, Jill M, Egan, Joanne, Hearne, Giovanni R, Marques, Helder M, Ntenteni, Skhumbuzo, Sewell, B Trevor, Smith, Peter J, Taylor, Dale, van Schalkwyk, Donelly A, Walden, Jason C
Publicado em 2002

Interference with Hemozoin Formation Represents an Important Mechanism of Schistosomicidal Action of Antimalarial Quinoline Methanols

Por Corrêa Soares, Juliana B. R., Menezes, Diego, Vannier-Santos, Marcos A., Ferreira-Pereira, Antonio, Almeida, Giulliana T., Venancio, Thiago M., Verjovski-Almeida, Sergio, Zishiri, Vincent K., Kuter, David, Hunter, Roger, Egan, Timothy J., Oliveira, Marcus F.
Publicado em 2009